摘要
目的 探讨血浆脑利钠肽 (BNP)浓度在慢性充血性心力衰竭 (心衰 ,CHF)时的变化及其临床诊断价值。方法 83例心脏病患者 ,根据有无并发心衰分为心衰组和非心衰组 ,在入院时测定血浆BNP浓度 ,并行心电图、胸部X线摄片、超声心动图检查。两位心脏科医生独立分析BNP结果 ,并结合患者所有的临床资料做出判断。结果 心衰组 5 7例 ,非心衰组 2 6例 ,BNP水平心衰组较非心衰组显著升高 (P <0 .0 0 1) ;BNP浓度随着心功能分级的增加而升高 ;BNP与超声心动图指标有很好的相关性。BNP诊断心衰的ROC曲线下面积 (AUC)为 0 .95 [( 95 %CI:0 .90～ 0 .99) ,P <0 .0 0 1]。结论 血浆BNP水平在慢性充血性心衰患者中明显升高 ,有助于确定心衰的诊断并能反映其严重程度。
Objective To evaluate the significance of brain natriuretic peptide(BNP) in patients with chronic congestive heart failure.Methods Plsma BNP were measured at arrival in 83 patients who had heart diease.The patients were also evaluated with electrocardiogram,chest roentgenogram,echocardiogram.Two cardiologist review all data of patients,then get the conclusion of heart failure or not,which was regarded as a gold criterion.Results There were 57 patients with congestive heart failure,26 patients without heart failure.Plasma BNP levels in patients with congestive heart failure were higher than that in patients without congestive heart failure (P<0.001).BNP levels rise when New York Heart Association exasperate.BNP levels were related to index of echography.BNP levels were accurate for the diagnosis of HF with an area under the receiver operating characteristic(ROC)curve(AUC)of 0.95[(95%CI:0.90-0.99),P<0.001].Conclusion Plsma BNP levels rise in patients with chronic congestive heart failure,which help to establish the diagnose of congestive heart failure and reflect the severity of them.
出处
《临床内科杂志》
CAS
北大核心
2004年第6期388-390,共3页
Journal of Clinical Internal Medicine
关键词
充血性心力衰竭
慢性
脑利钠肽
Brain Natriuretic Peptide
Congestive Heart Failure, chronic
