摘要
目的 观察大豆异黄酮治疗冠心病伴高胆固醇血症患者的疗效 ,及其对血脂达标率的影响。方法 将 78例冠心病伴高胆固醇血症患者随机分为三组 ,各组 2 6例 ,每天分别给予辛伐他汀 2 0mg(辛伐他汀组 )、大豆异黄酮 15 0mg(异黄酮组 ) ,二药合用组 ,疗程为 8周。结果 辛伐他汀、大豆异黄酮均降低总胆固醇 (TC)、低密度脂蛋白 胆固醇 (LDL C)载脂蛋白B10 0 (ApoB10 0 )和脂蛋白 (a) [Lp(a) ] (P <0 .0 5及 0 .0 1) ;二药合用组TC、LDL C、降低效果明显优于各自单用药组 ,达标率明显提高 ( 69%比 2 3 %、19% ,P <0 .0 1) ,血清甘油三酯 (TG)降低 ,高密度脂蛋白 胆固醇 (HDL C)、载脂蛋白A1(ApoA1)升高 (P <0 .0 1)。结论 大豆异黄酮全面改善血脂 ,与他汀类合用效果更显著 ,并大幅度提高达标率。
Objective To observe the curative effect of isoflavones on dislipidaemia and success rate in patients with coronary heart disease(CHD).Methods 78 hypercholesterolaemia patients with CHD were randomly into three groups(n=26 for each group),received therapy with simvastatin 20mg/d,isoflavones 150mg/d alone or together,respectively.The therapy continued for 8 weeks.Results After therapy with isoflavones or simvastatin alone, total cholesterol(TC)、low density lipoprotein cholesterol(LDL-C)、apoprotein B100(ApoB100)、lipoprotein (a)[Lp(a)] were decreased(P<0.05 and 0.01).The decrease in TC、LDL-C were superior and success rate was increased remarkably while therapy together,compared with isoflavones or simvastatin alone (69% vs 23%、19%,P<0.01).Besides,triglyceride(TG) was decreased、high density lipoprotein cholesterol(HDL-C) and apoprotein A1(ApoA1) increased(P<0.01).Conclusion Isoflavones improve dislipidaemia generally in patients with CHD.When combined with simvastatin therapy,the curative effect and success rate is remarkably superior to isoflavones or simvastatin alone.
出处
《临床内科杂志》
CAS
北大核心
2004年第6期393-394,共2页
Journal of Clinical Internal Medicine
基金
广东省韶关市科委重点科技资助项目 (Y2 0 0 30 31 7)
关键词
高胆固醇血症
冠状动脉疾病
辛伐他汀
异黄酮
Hypercholesterolaemia
Coronary artery disease
Simvastatin
Isoflavones
