摘要
目的 探讨孕产妇感染乙型肝炎病毒 (HBV)对母婴的影响及可采取的预防措施。方法 以 1 81例乙肝表面抗原 (HBsAg)阳性的孕妇作为研究组 ,同期 2 0 0例HBsAg阴性孕妇作为对照组 ,全程观察两组妊娠经过、围产儿预后、产时并发症、新生儿及婴儿HBV感染状况。结果 研究组新生儿脐血HBsAg阳性 1 9例 ,检出率 1 1 95 % ;1月龄、6月龄静脉血阳性 7例 ,检出率 4 40 % ;对照组为 0。胎儿丢失研究组与对照组相比较有显著差异 (P <0 0 5 ) ;新生儿窒息、产后出血研究组与对照组有特别显著差异(P <0 0 1 ) ;而新生儿出生缺陷两组相比较无显著差异 (P >0 0 5 )。结论 孕产妇感染HBV可引起胎儿宫内感染 ,导致胎儿丢失的危险性增加 ,HBsAg、HBeAg双阳性的孕妇尤为突出 ,应加强孕期保健 ,酌情终止妊娠 。
Objective To explore the influence of HBV infection of pregnant women on the mother and baby as well as available prevention and treatment.Methods we took 181 cases of HBsAg-positive pregnant women as the research group and 200 cases of HBsAg-negative pregnant women during the same period as the control group to observe the whole pregnant couse, perinatal infants' outcome, complications during parturition, as well as the HBV-infecting status of the neonates and infants.In the research group.Results HBsAg test was positive in 19 neonates(11.95%)sampled from umbilical blood, in another 7 cases(4.40%)diagnosed in one month and six months later sampled from venous blood, whereas HBsAg test was all negative in control group. Between the two groups, the significant differences were found as for fetal loss(P<0.05), neonates’asphyxia and post-birth bleeding P<0.01); but not as to neonates’developmental deficiency(P>0.05).Conclusion The rates of (abortion, stillbirth)as well as of the research group were higher than the control one .In conclusion, intrauterine infection with HBV of fetuses through the involved women could increase the risk of the fetal loss ,especially in HBsAg and HBeAg double-positive situation, for which pregnant heath care should be strengthen and it might be reasonable to terminate the pregnancy during the early stage ,of passive and active immunity may prevent the materno-infant transmission effectively.
出处
《兰州医学院学报》
2004年第2期31-33,共3页
Journal of Lanzhou Medical College
关键词
孕妇
乙肝病毒
病毒感染
母婴传播
HBV
Hepatitis B virus(HBV) Prognosis of perinatal infants Materno-infant transmission
