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干扰素调节因子家族 被引量：1

Interferon Regulatory Factor Family
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摘要 干扰素调节因子（IRFs）是调节干扰素（IFN）、干扰素刺激性应答基因（ISG）及其它相关基因表达的重要转录因子,通过调节IFN、ISG和其它密切相关基因表达而发挥多种生物学效应. Interferon regulatory factors (IRFs) are some of important transcriptional factors for regulating the expression of interferon (IFN) and interferon stimulated genes (ISG) as well as the genes related to IFN signal transduc-tion.The multiple biological effects of the members of interferon regulatory factor family have been shown to be mediated by the transcriptional activation for IFN, ISG and the related genes.
作者 李新梅 陈汉春
机构地区 中南大学湘雅医学院 分子生物学研究中心
出处 《生命科学研究》 CAS CSCD 2002年第S1期8-12,共5页 Life Science Research
关键词 干扰素 干扰素调节因子 干扰素刺激性应答基因 interferon interferon regulatory factor interferon stimulated gene
分类号 Q51 [生物学—生物化学]
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参考文献29

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  • 2IMAIZUMI Y,KOHNO T,YAMADA Y,et al.Possible Involvement of Interferon Regulatory Factor 4 (IRF4) in a Clinical Subtype of Adult T-Cell Leukemia. Japanese Journal of Cancer Research . 2001
  • 3HISCOTT J,PITHS P.CENIN P,et al.Triggering the interferon re-sponse:the role of IRF-3 transcription factor. Journal of Interferon and Cytokine Research . 1999
  • 4WILLMAN C L,SEVER C E,PALLAVICINI M G,et al.Deletion of IRF-1, mapping to chromosome 5q31. 1, in human leukemia and preleukemic myelodysplasia. Science . 1993
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  • 7ROSENBAUER F,WARING J F,FOERSTER J,et al.Interferon consensus sequence binding protein and interferon regulatoiy fac-tor-4/Pip form a complex that represses the expression of the inter-feron-stimulated gene-15 in macrophages. Blood . 1999
  • 8LAU J F,PARISIEN J P,KALVAKOLANU D V,et al.Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors. Proceedings of the National Academy of Sciences of the United States of America . 2000
  • 9CONTURSI C,WANG I M,CABRIELE L,et al.IFN consensus sequence binding protein potentiates S’TAT1-dependent activation of IFNgamma-responsive promoters in macrophages. Immunology . 2000
  • 10CUPTA S,JIANG M,ANTHONY A,et al.Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4. The Journal of Experimental Medicine . 1999

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生命科学研究
2002年 第S1期

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