摘要
目的 :观察天年饮 (Tiannianyin,TNY)对亚急性衰老大鼠血清睾酮含量及睾丸生精细胞凋亡的影响。方法 :采用 D-半乳糖连续腹腔注射制作亚急性衰老大鼠模型 ,检测 TNY灌胃前后大鼠血清睾酮含量及睾丸生精细胞凋亡的情况。结果 :D-半乳糖致亚急性衰老大鼠血清睾酮含量明显下降 ,与正常大鼠比较差异显著 (P<0 .0 5 ) ;经 TNY灌胃后其含量升高接近正常水平 ,与模型大鼠相比有明显差异 (P<0 .0 5 )。D-半乳糖致亚急性衰老大鼠睾丸曲细精管凋亡百分率及凋亡细胞阳性率均升高 ,与正常组比较差异显著 (P<0 .0 5 ) ;经 TNY灌胃后 ,二者均降低 ,与模型大鼠比较有明显差异 (P<0 .0 5 )。结论 :TNY可提高亚急性衰老大鼠血清睾酮含量及降低衰老大鼠睾丸生精细胞的凋亡指数 。
Objective:To study the effect of Tiannianyin(TNY)on testestrone level inserum and apoptosis of the germ cell in sub acutely aging rats.Methods:The model of sub acutely rats were made by injecting D gal into the abdominalcavity continually.Then the testesterone level in serum and apoptosis of the germ cells were detected before and after taking TNY.Results:The testesterone level in serum of sub acutely aging rats decreased significantly compared with control rats(P<0.05)the testestrone level increased after taking TNY.Results:The testesterone level in serum of sub acutely aging rats decreased significantly compared with model rats:P<0.05).Apoptosis cell sin sub acutely aging rats increased significantly compared with control rats (P<0.05)and after taking TNY it decreased (P<0.05).Conclusion:TNY may has fairly anti aging effect on D gal treated rats gonad.
出处
《承德医学院学报》
2004年第2期106-108,共3页
Journal of Chengde Medical University
关键词
天年饮
亚急性衰老
睾丸
睾酮
凋亡
TNY
sub acutely aging
testis
testestrone
apoptosis
