摘要
目的:探讨高脂血症中红细胞膜Ⅰ型补体受体(RBC—CR_1)的变化。方法:采用补体致敏酵母多糖,测定高脂血症患者RBC—CR_1的变化。结果:血浆中载脂蛋白B(apoB),甘油三酯(TG),总胆固醇(TC)和红细胞膜(RBC—m)TC,载脂蛋白A(ApoA),ApoA/ApoB升高者RBC—CR_1花环率降低,与对照组比较,差异显著,分别为对照组13.9±2.2％,高脂血症组10.5±2.6％(P<0.01)。结论:高脂血症患者红细胞免疫粘附功能调节降低,脂类代谢失衡造成免疫复合物的堆积,封闭了红细胞膜上CR_1的位点,阻碍了免疫复合物充分粘附在红细胞膜上,使其不能及时清除大量的沉积脂质,促进了动脉粥样硬化形成。
Objective: To study significance of changes of complement receptor I on erythrocyte membrance(RBC-CR1) of hyperlipemia patients. Method: RBC -CR1 of hyperlipemia patients was determined by complement sensitizing yeast polysaccharide and compared with that of normal subjects. Results: The flower - ring forming rate of patients' RBC - CR1decreased significantly (13. 9±2. 2% vs. 10. 5±2. 6%). Conclusion: Erythrocyte immune adhesion of hyperlipemia patients decreases, which is induced by immunocomplex accumulation resulted from lipodystrophy and RBC - CR1 was blocked. Therefore, an amount of sedimented lipid can not be eliminated and atherosclerosis occurs.
出处
《西南国防医药》
CAS
1999年第4期196-198,共3页
Medical Journal of National Defending Forces in Southwest China
