摘要
目的 了解H_1和H_2受体在肝硬变门静脉高压症大鼠和病人肝组织中的变化。方法 应用~3H-吡拉明和~3H-甲氰咪胍对四氯化碳诱导的10只大鼠肝硬变模型和8例乙型肝炎后肝硬变病人的肝组织进行光学放射自显影研究。结果 肝组织结构的H_1、H_2受体密度(每1000μm^2银粒计数)对照组/肝硬变大鼠分别为,H_1受体:肝细胞346.5±31.8/116.9±17.7,肝静脉276.9±17.6/27.1±4.6,肝动脉31.4±6.9/12.4±3.1,肝门静脉24.7±10.7/15.8±3.8;H_2受体:肝细胞288.9±21.2/168.0±23.7,肝动脉234.6±8.7/153.7±25.2,肝门静脉229.8±28.3/148.3±18.0,肝静脉261.3±35.8/141.0±18.3。对照组/肝硬变病人H_1受体:肝细胞68.7±8.7/63.1±5.5,肝动脉40.6±7.5/35.5±4.7,肝门静脉38.8±5.2/34.4±6.8,肝静脉35.6±8.2/34.7±5.0;H_2受体:肝细胞511.9±37.6/168.4±22.6,肝动脉175.4±26.1/55.6±7.1,肝门静脉166.4±17.7/52.0±5.4,肝静脉313.0±52.4/238.8±40.7。结论 大鼠以H_1受体占优势,人以H_2受体为主;肝硬变大鼠及病人肝组织结构上的H_1、H_2受体低于对照组。
Objective To know the sensity of H1 and H2 receptors on hepatic tissues of cir-rhotic rats and cirrhotic patients with portal hypertension. Methods 10 Wistar rats of CCl4-induced cirrhosis and 8 cases of hepatitis virus B-related cirrhosis were studied. A light autoradiography was used. Results The density of H1 and H2 receptors on hepatic tissue s (per 1000μm2 ) in rats(comtrol/ cirrhosis)were (H1 receptor)346.5 ±31.8/116.9±17.7 for hepatocyter (HC),31.4±6.9/12.4±3.1 for intraheptic artery walls (HA), 24.7±10.7/15.8±3. 8 for intrahepatic portal walls(PV), 276.9±17.6/27.1±4.6 for hepatic venule walls (HV); (H2 receptor)288.9±21.2/168.0±23. 7 for HC,234.6±8.7/153.7±25.2 for HA,229.8±28.3/148.3±18.0 for PV,261.3±35.8/141. 0±18.3 for HV;The density of H1 and H2 receptors on hepatic tissues in patients(control/cirrhosis) were(H1 receptor)68.7±8.7/63.1±5.5 for HC,40.6±7.5/35.5±4.7 for HA, 38.8±5.2/34.4±6.8 for PV,35.6±8.2/34.7±5.0 for HV;(H2 receptor)511. 9±37. 6/168.4± 22. 6 for HC, 175.4±26.1/55.6±7.1 for HA, 166.4±17.7/52.0±5.4 for PV,313.0±52.4/238.8±40.7 for HV.Conclusion The density of H1 and H2 receptors on various hepatic structures in cirrhotic rats and cirrhotic patients are significantly lower than that in control rats and patients.
出处
《解放军医药杂志》
CAS
1999年第2期81-85,共5页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
基金
国家自然科学基金
