摘要
为了观察骨形态形成蛋白对老龄性骨质疏松性骨折愈合的成骨促进作用，作者选用２４月龄老龄大白鼠，凿去双侧胫骨上中１／３交界处相同部位的部分骨质，保留后侧骨皮质，以制成骨折缺损模型。严格配对后分成两组。一组骨缺损内注入小牛骨形态形成蛋白，另一组注入生理盐水作对照。通过对大鼠实验前后血清钙浓度、碱性磷酸酶活性、骨痂的数量和质量的观察，证实骨形态形成蛋白能刺激老龄鼠骨内成骨细胞活性，加快骨形成，提高骨质量，从而促进骨折缺损的愈合。
Twenty 24 month old SD rats were used to investigate the effects of bone morphogenetic protein (BMP) on the healing of senile osteoporotic fracture in rats. The tibial draft defects were created between the upper 1/3 and the middle 1/3. BMP was injected into 20 defects of 10 rats, and normal saline solution was injected into the other 20 defects as control. Serum calcium concentration, activity of serum alkaline phosphatase before and after the injection were tested. The quantity of callus, bone histomorphometry of trabecular bone, osteoblastic surface, and mineralized trabecular surface ratio in the defects were measured correspondingly. The results showed that BMP could accelerate the healing of senile osteoporotic fracture in rats.
出处
《中山大学学报（医学科学版）》
CAS
CSCD
1997年第S1期70-73,共4页
Journal of Sun Yat-Sen University:Medical Sciences
基金
中山医科大学科研基金
