摘要
应用Bayesian反馈法,预测21例高血压病人口服阿替洛尔的个体药动学参数及稳态血药浓度C_(pss),并与经典药动学方法估算的结果比较。本法的T_(1/2)为(6.0±1.7)h,Vd为(1.43±0.13)L/kg,CL为(172±34)ml·h^(-1)·kg^(-1);经典法的T_(1/2)为(6.8±2.4)h,Vd为(1.45±0.56)L/kg,CL为(164±85)ml·h^(-1)·kg^(-1)。两者无显著性差异(P>0.05),两法所测得C_(pss)有较好相关性(r=0.993)。
Bayesian approach was applied for predicting the individual pharmacokinetic pa-rameters and stead-state blood concentration of atenolol after oral administration in 21 patients with hypertension. The results indicated that predicting pharmacokinetic parameters with Bayesian feedback method were, T1/2(6.0±1.7)h, Vd(1. 43±?0.13)L/kg, CL(172±34)ml·h -1 ·kg-1 respectively; and estimating pharmacokinetic parameters with two steps method were, T1/2(6.8±2.4)h, Vd(1.45±0.56)L/kg, CL(164?±85)ml·h-1·kg-1spectively. The former showed no significant difference as compared with the latter(P>0. 05). The relativity was good between the forecasted and observed stead-state plasma concentration( r = 0. 993).
出处
《解放军药学学报》
CAS
1997年第1期5-7,共3页
Pharmaceutical Journal of Chinese People's Liberation Army
