摘要
肾移植术后因免疫抑制剂的应用可出现药物性肝损害(DILI)。笔者观察肾移植手术124例,发生药物肝损害23例,占18.6％,其中21例治愈,2例死亡。肾移植术后肝损害治疗的原则:(1)调整免疫抑制剂用量;(2)应用肝细胞生长素(HGF)促进肝细胞再生;(3)综合支持治疗。术后定期监测肝功能对保证移植肾术后长期存活有极其重要意义。
Drug-induced liver injury can be caused by application of immuno-suppressant after renal transplantation. 124 cases of renal transplantation were observed. There occurred 23 cases of drug-induced liver injury(18. 6% ) ,21 were cured and 2 died. The cure principles are:regulation of the dosage of immunosuppressant, application of hepatic growth factor to enhance the regeneration of hepatic cells and combined supporting treatment. Periodical postoperative monitoring of liver function is essential to long survival after renal transplantation.
关键词
肾移植
药物
肝损害
renal transplantation
drug
liver injury
