摘要
洞庭湖疫区82例血吸虫病肝纤维化(SF)患者存在着明显的红细胞和T细胞免疫功能失调.表现在红细胞膜C_3b受体活性(RBC-C_3b)降低,红细胞膜上免疫复合物(RBC-IC)增多,T细胞总数(CD_2)、T辅助细胞(CD_4)阳性率下降,T抑制细胞(CD_8)升高,CD_4/CD_8比值下降,RBC-C_3b与CD_2、CD_4呈显著性正相关.经中药制剂抗纤灵治疗后,治疗组RBC-C_3上升,RBC-IC下降,CD_2、CD_4及CD_4/CD_8亦上升;与西医常规治疗组比较有显著意义.本研究证实,抗纤灵对红细胞和T细胞亚群免疫功能具有调节作用.
The obvious immune dysfunctions of erythrocytes and subsets of T-cells were found in 82 cases with hepatic fibrosis of schistosomiasis in the endemic area of Dong Ting lake. If was showed that the activity of RBC-C3b (RBC membranous C3b receptor) was lower,but the RBC-IC (RBC membranous immunocomplex) was elevated. The total count of T-cells and positive rate of T-helper cells were decreased,howerer the T-inhibitor cells were increased, the ratio of CD4/CD8 was declined. The RBC-C3b had a significant positive corretation with CD2,CD4. After administration of kangxianling (KXL), RBC-C3b,CD2, CD4 and CD4/CD8 were raised,but RBC-IC was decreased in the expermental group. Compared with the routine treatment of western medicine, the statistically significant difference was made. The study demonstrated that KXL played a role in immunregulation of erythrocytes and subsets of T-cells.
出处
《中国血吸虫病防治杂志》
CAS
CSCD
1996年第4期212-215,共4页
Chinese Journal of Schistosomiasis Control
基金
国家自然科学基金资助课题(No.39190929)
关键词
抗纤灵
血吸虫病肝纤维化
红细胞免疫
T细胞亚群
Kangxianling,Schistosomiatic hepatic fibrosis,Subgroups of T-cells,erythrocytic immunity
