摘要
在感染率为38.1%的山丘型日本血吸虫病流行区,吡喹酮普治后1年人群血吸虫再感染率为12.6%,成人暴露水平很高但再感染率不高,而未成年人的暴露水平很低但再感染率却很高.根据个体暴露和再感染状况的不同,获得两组人群;一组是低暴露而治后再感染者为易感组,共8例,均为男性;另有一组,尽管高度暴露但治后未再感染者为拮抗组,共80例,其中男性33例,女性47例.结果显示:拮抗组的平均年龄(31.7岁)比易感组(21.0岁)大10.7岁,提示一种年龄依赖的、迟发的获得性免疫在日本血吸虫再感染中可能起着重要作用.
Exposure and reinfection after treatment with praziquantel were observed in a hilly rural community where the overall prevalence of pretreatment infection with Schistosoma japon-icum was 38.1%. The individual exposure to infection was estimated using the Index E. Results showed that the reinfection rate one year after treatment was 12. 6%. High level of exposure but low level of reinfection could be found in the adults, however, low level of exposure but high level of reinfection could be found in the children or young adolescents. 8 individuals who were reinfected with Schistosoma japonicum only one year after mass chemotherapy were considered to be susceptible to reinfection,all of them were male;The other 80 individuals who remained un-reinfected even highly exposed to infection during the same period were considered to be resistant,among them 33 were male and 47 were female. Comparing these two groups,it was found that the average age of resistant group was 10. 7 years older than that of susceptible group,thus,it seems that age is a very important factor affecting the individual reinfection;an age-related,acquired immunity may play important role in the reinfection with Schistosoma japonicum.
出处
《中国血吸虫病防治杂志》
CAS
CSCD
1996年第3期129-132,共4页
Chinese Journal of Schistosomiasis Control
基金
"八五"攻关课题85-917-02-02
关键词
暴露
再感染
日本血吸虫
山丘型
exposure,reinfection,Schistosoma japonicum,moutainous endemic area
