摘要
本文首次在国内报告运用甲基强的松龙冲击疗法合并大剂量环磷酰胺每月静脉疗法,治疗8例重症肾炎患者(Ⅳ型狼疮性肾炎2例,新月体肾炎及结节性多动脉炎各3例),取得一定疗效。该疗法不仅能迅速缓解急性期症状,而且亦可延缓慢性病变,改善长期预后.治疗后不论外周血还是肾组织中的淋巴细胞,CD_4、CD_3水平均有明显下降,但有2例患者发生粒细胞缺乏症,故应严格掌握适应证.
Eight patients with severeglomerulonephritis,including 2 cases of severe lupus nephritis,3 cases of crescentic glomeruloneph- ritis and 3 cases of polyarteritis nodosa were treated with pulse methyl- prednisolone therapy and monthy intravenous eyelophosphamide therapy. The clinical manifestations and laboratory findings improved markedly, and the level of lymphocytes (CD4 and CD8) both in the blood and renal tissues declined significantly after therapy.Methylprednisolone and cyclophosphamide were effective immune surpressive agents.
出处
《医学研究生学报》
CAS
1992年第3期197-199,277,共4页
Journal of Medical Postgraduates
关键词
甲基强的松尤
环磷酰胺
每月静脉疗法
重症肾炎
pulse methylprednisolone
cyclophosphamide
monthly intravenous
glomerulonephritis
