摘要
精确的实验测定表明:距离毛细血管150～200μm以上的肿瘤细胞氧张力几降为零,显然在氧张力梯度变化的路径上存在有这样的区域,那里的肿瘤细胞既获得有保存致克隆源性足够高的氧分压,而同时这又是抗拒放射损伤足够低的氧分压。这为临床放射治疗带来了麻烦。
Comprehensive investigations have suggested that attempt to improve the efficacy of tumor radiotherapy is directed towards the control of hypoxic cells. The partial pressure of oxygen in some of the hypoxic cells is high enough to keep them surviving, while low enough to keep resisting against radiation damage. An increased radical dose should be delivered, but will be limited by the threshold of the tolerance of the normal tissues near the tumor. In the present experiment, using a transient total body hypoxia induced by breathing a gas mixture with 10.5% oxygen, mice were irradiated, and using the yield of destroyed intestinal crypts as criterion of the radiation effect, a radiopro-tective factor (RPF) of 1,37 was obtained. There will be a possibility to permit the administration of an increased tumor dose in clinic trials.
出处
《中华放射肿瘤学杂志》
CSCD
1991年第1期47-49,共3页
Chinese Journal of Radiation Oncology
