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Role of hemostatic powders in the endoscopic management of gastrointestinal bleeding 被引量:3

Role of hemostatic powders in the endoscopic management of gastrointestinal bleeding
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摘要 Acute gastrointestinal bleeding(AGIB) is a prevalent condition with significant influence on healthcare costs. Endoscopy is essential for the management of AGIB with a pivotal role in diagnosis, risk stratification and management. Recently, hemostatic powders have been added to our endoscopic armamentarium to treat gastrointestinal(GI) bleeding. These substances are intended to control active bleeding by delivering a powdered product over the bleeding site that forms a solid matrix with a tamponade function. Local activation of platelet aggregation and coagulation cascade may be also boosted. There are currently three powders commercially available: hemostatic agent TC-325(Hemospray), EndoClotTM polysaccharide hemostatic system, and Ankaferd Bloodstopper. Although the available evidence is based on short series of cases and there is no randomized controlled trial yet, these powders seem to be effective in controlling GI bleeding from a variety of origins with a very favorable side effects profile. They can be used either as a primary therapy or a secondline treatment, and they seem to be especially indi-cated in cases of cancer-related bleeding and lesions with difficult access. In this review, we will comment on the mechanism of action, efficacy, safety and technical challenges of the use of powders in several clinical scenarios and we will try to define the main current indications of use and propose new lines of research in this area. Acute gastrointestinal bleeding(AGIB) is a prevalent condition with significant influence on healthcare costs. Endoscopy is essential for the management of AGIB with a pivotal role in diagnosis, risk stratification and management. Recently, hemostatic powders have been added to our endoscopic armamentarium to treat gastrointestinal(GI) bleeding. These substances are intended to control active bleeding by delivering a powdered product over the bleeding site that forms a solid matrix with a tamponade function. Local activation of platelet aggregation and coagulation cascade may be also boosted. There are currently three powders commercially available: hemostatic agent TC-325(Hemospray), EndoClotTM polysaccharide hemostatic system, and Ankaferd Bloodstopper. Although the available evidence is based on short series of cases and there is no randomized controlled trial yet, these powders seem to be effective in controlling GI bleeding from a variety of origins with a very favorable side effects profile. They can be used either as a primary therapy or a secondline treatment, and they seem to be especially indi-cated in cases of cancer-related bleeding and lesions with difficult access. In this review, we will comment on the mechanism of action, efficacy, safety and technical challenges of the use of powders in several clinical scenarios and we will try to define the main current indications of use and propose new lines of research in this area.
出处 《World Journal of Gastrointestinal Pathophysiology》 CAS 2014年第3期284-292,共9页 世界胃肠病理生理学杂志(英文版)(电子版)
关键词 GASTROINTESTINAL HEMORRHAGE ENDOSCOPY POWDERS ENDOSCOPIC HEMOSTASIS Gastrointestinal hemorrhage Endoscopy Powders Endoscopic hemostasis
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参考文献11

  • 1Gokhan Gungor,M Hakan Goktepe,Murat Biyik,Ilker Polat,Tuncer Tuna,Huseyin Ataseven,Ali Demir.Efficacy of ankaferd blood stopper application on nonvariceal upper gastrointestinal bleeding[J].World Journal of Gastrointestinal Endoscopy,2012,4(12):556-560. 被引量:5
  • 2Gabriele Curcio,Antonino Granata,Mario Traina.Hemospray for multifocal bleeding following ultra‐low rectal endoscopic submucosal dissection[J].Digestive Endoscopy.2014(4)
  • 3Michael Sulz,Remus Frei,Christa Meyenberger,Peter Bauerfeind,Gian-Marco Semadeni,Christoph Gubler.Routine use of Hemospray for gastrointestinal bleeding: prospective two-center experience in Switzerland[J].Endoscopy.2014
  • 4Ilaria Tarantino,Luca Barresi,Antonino Granata,Gabriele Curcio,Mario Traina.Hemospray for arterial hemorrhage following endoscopic ultrasound-guided pseudocyst drainage[J].Endoscopy.2014
  • 5Thomas Kratt,Jessica Lange,Alfred K?nigsrainer,Nisar Malek,Patrick Adam,Hans B?smüller,Martin Goetz.Successful Hemospray treatment for recurrent diclofenac-induced severe diffuse lower gastrointestinal bleeding avoiding the need for colectomy[J].Endoscopy.2014
  • 6Rui Huang,Yanglin Pan,Na Hui,Xuegang Guo,Linhui Zhang,Xiangping Wang,Rongchun Zhang,Hui Luo,Xiong Zhou,Qin Tao,Zhiguo Liu,Kaichun Wu.Polysaccharide hemostatic system for hemostasis management in colorectal endoscopic mucosal resection[J].Digestive Endoscopy.2014(1)
  • 7Samuel Giday,William Alstine,John Vleet,Richard Ducharme,Eric Brandner,Madalina Florea,Krystal Johnston,Jose Negron-Garcia,Kimberly Ringenberger.Safety Analysis of a Hemostatic Powder in a Porcine Model of Acute Severe Gastric Bleeding[J].Digestive Diseases and Sciences.2013(12)
  • 8I. Holster,Enric Brullet,Ernst Kuipers,Rafel Campo,Alberto Fernández-Atutxa,Eric Tjwa.Hemospray treatment is effective for lower gastrointestinal bleeding[J].Endoscopy.2013
  • 9Sarah Leblanc,Ariane Vienne,Marion Dhooge,Romain Coriat,Stanislas Chaussade,Frédéric Prat.Early experience with a novel hemostatic powder used to treat upper GI bleeding related to malignancies or after therapeutic interventions (with videos)[J].Gastrointestinal Endoscopy.2013(1)
  • 10Antonino Granata,Gabriele Curcio,Neville Azzopardi,Luca Barresi,Ilaria Tarantino,Mario Traina.Hemostatic powder as rescue therapy in an H1N1 patient with uncontrolled colonic bleeding[J].Gastrointestinal Endoscopy.2013

二级参考文献15

  • 1Johnston,JH.Endoscopic risk factors for bleeding peptic ulcer. Gastrointestinal Endoscopy . 1990
  • 2RT Yavorski,RK Wong,C Maydonovitch,LS Battin,A Furnia,DE Amundson.Analysis of 3,294 cases of upper gastrointestinal bleeding in military medical facilities. The American journal of Gastroenterology . 1995
  • 3Bleau BL,,Gostout CJ,,Sherman KE,,Shaw MJ,,Harford WV,,Keate RF,, Bracy WP,,Fleischer DE.Recurrent bleeding from peptic ulcer associated with adherent clot: a randomized study comparing endoscopic treatment with medical therapy. Gastrointestinal Endoscopy . 2002
  • 4Adler DG,Leighton JA,Davila RE,Hirota WK,Jacobson BC,Qureshi WA,Rajan E,Zuckerman MJ,Fanelli RD,Hambrick RD,Baron T,Faigel DO.ASGE guideline: The role of endoscopy in acute non-variceal upper-GI hemorrhage. Gastrointestinal Endoscopy . 2004
  • 5M Kurt,S Kacar,IK Onal,M Akdogan,IC Haznedaroglu.Ankaferd Blood Stopper as an effective adjunctive hemostatic agent for the management of life-threatening arterial bleeding of the digestive tract. Endoscopy . 2008
  • 6Goker H,Haznedaroglu IC,Ercetin S,Kirazli S,Akman U,Ozturk Y,Firat HC.Haemostatic actions of the folkloric medicinal plant extract Ankaferd Blood Stopper. Journal of International Medical Research . 2008
  • 7Kurt M,Akdogan M,Onal IK,Kekilli M,Arhan M,Shorbagi A,Aksu S,Kurt OK,Haznedaroglu IC.Endoscopic topical application of Ankaferd Blood Stopper for neoplastic gastrointestinal bleeding: A retrospective analysis. Digestive and Liver Disease . 2010
  • 8Ozaslan E,Purnak T,Yildiz A,Haznedaroglu IC.A new practical alternative for tumoural gastrointestinal bleeding: Ankaferd blood stopper. Digestive and Liver Disease . 2010
  • 9Purnak T,Ozaslan E,Beyazit Y,Haznedaroglu IC.Upper gastrointestinal bleeding in a patient with defective hemostasis successfully treated with ankaferd blood stopper. Phytotherapy Research . 2011
  • 10Tuncer I,Doganay L,Ozturk O.Instant control of fundal variceal bleeding with a folkloric medicinal plant extract: Ankaferd Blood Stopper. Gastrointestinal Endoscopy . 2010

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