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白癜风患者血清及皮损疱液中IL-18、IL-33水平的变化及意义 被引量：3

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摘要 目的检测白癜风患者血清及皮损疱液中IL-18、IL-33水平,探讨上述因子在白癜风发病过程中的可能作用。方法采用ELISA法测定79例白癜风患者(稳定期25例,进展期41例)、27例健康人血清及25例接受表皮移植的稳定期白癜风患者皮损疱液中IL-18、IL-33水平,并进行比较。结果患者进展期血清中IL-18含量高于稳定期及健康对照(P均<0.05),稳定期与健康对照含量无统计学差异。接受表皮移植患者皮损区疱液中IL-18含量显著高于供皮区(P<0.05)。IL-33在白癜风患者与健康对照血清及患者皮损区与供皮区疱液比较中均未见差异有统计学意义。结论 IL-18作为炎症因子可能在白癜风发病进展期发挥一定作用,特别是在皮损区的异常表达可能参与了黑色素细胞的破坏过程。
作者 王丽欣 李洋
机构地区 青岛大学医学院附属医院西院区 青岛监狱医院
出处 《山东医药》 CAS 2013年第37期82-83,共2页 Shandong Medical Journal
关键词 白癜风 白细胞介素18 白细胞介素33 酶联免疫吸附法
分类号 R758.41 [医药卫生—皮肤病学与性病学]
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参考文献12

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共引文献3

同被引文献26

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引证文献3

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山东医药
2013年 第37期

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