摘要
目的 探讨糖代谢异常对肝硬化并发症的影响.方法 以2005年1月1日至2007年12月31日上海市第一人民医院消化内科494例肝硬化住院病例为研究对象,其中男293例,女201例,年龄(62±14)岁,回顾性分析糖代谢异常对肝硬化并发症的影响.计量资料比较采用t检验,计数资料采用卡方(X^2)检验,并计算比值比(OR值),P＜0.05为差异有统计学意义.结果 494例肝硬化中191例糖代谢异常,303例糖代谢正常.糖代谢异常者发生上消化道出血104/191例,脾功能亢进141/191例,高于糖代谢正常者的97/303例和194/303例,OR值分别是2.539和1.584,均P＜0.05.根据病毒性肝炎、嗜酒因素进行分层后,在无病毒性肝炎、不嗜酒的病例中,糖代谢异常发生上消化道出血和脾功能亢进的OR值分别是2.653和2.640,均P＜0.05.年龄分为＜50岁、50～70岁、＞70岁三组后,糖代谢异常均可增加肝硬化患者并发上消化道出血的发病危险性(OR值分别为3.314、2.233、2.425,均P＜0.01).结论 糖代谢异常是肝硬化患者发生上消化道出血和脾功能亢进的危险因素,且独立于病毒性肝炎和嗜酒.年龄分层后,糖代谢异常仍是肝硬化患者并发上消化道出血的危险因素.
Objective To investigate the influence of glucose metabolism disorders on complications of cirrhosis.Methods A total of 494 residence cirrhosis patients(293 males,201 females,mean age 62±14 y)attending the Department of Gastroenterology of First People's Hospital from 1st January 2005 to 31th December 2007 was enrolled.The influence of glucose metabolism disorders on complications of cirrhosis was retrospectively analyzed.Quantitative data were ananylzed by t test.Categorical data were analyzed by X^2 test and OR were caculated.P vaule＜0.05 was considered satistically significant.Results In 494 cases of liver cirrhosis,191 patients had glucose metabolism disorders while 303 patients were normal.In patients with glucose metabolism disorders,the rates of gastrointestinal hemorrhage and hypersplenism were 104/191 and 141/191 respectively,which were higher than those in the patients with normal glucose metabolism.The OR was 2.539 and 1.584 respectively(aU P＜0.05).After stratifying according to viral hepatitis and alcohol addiction,in patients who had glucose metabolism disorders without viral hepatitis and alcohol addiction.the OR of upper gastrointestinal hemorrhage and hypersplenism was 2.653 and 2.640 respectively(all P＜0.05).In all of 3 different age groups(＜50 y,50～70 y,＞70 y),glucose metabolism disorders could increase the risk of the upper gastrointestinal hemorrhage(the OR was 3.314,2.233,2.425,all P＜0.01).Conclusion Glucose metabolism disorders is a risk factor of upper gastrointestinal hemorrhage and hypersplenism in cirrhosis patients,which is independent on viral hepatitis and alcohol addiction.After stratifying according to age,glucose metabolism disorders is still a risk factor of upper gastrointestinal hemorrhage.
出处
《中华糖尿病杂志》
CAS
2009年第4期-,共4页
CHINESE JOURNAL OF DIABETES MELLITUS
基金
国家教育部新世纪优秀人才支持计划资助项目
