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胃癌干细胞的研究进展及面临的挑战

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摘要 胃癌是当今严重威胁人类健康的恶性肿瘤之一,其病因至今仍未阐明.胃癌的治疗尚缺乏有效对策,虽然进展期胃癌有各种治疗方式(如手术、放化疗、免疫治疗、基因治疗等),但胃癌的病死率依然居高不下,其5年总体生存率不足40％.因此,了解胃癌的发病机制是现今研究中迫切需要解决的课题. 肿瘤干细胞理论是近年来兴起的理论,并且受到学者们广泛关注.胃癌干细胞的研究为胃癌的治疗开辟了一个新的方向:肿瘤的治疗方式或许可以由传统的治疗方式(尽量减少肿瘤体积和癌细胞数量)转向靶向杀死肿瘤干细胞的治疗方式.本文就胃癌干细胞的研究进展和面临的挑战进行综述.
作者 张明凯 李玉明
机构地区 山东滨州医学院附属医院胃肠外科
出处 《消化肿瘤杂志（电子版）》 2011年第4期260-262,共3页 Journal of Digestive Oncology(Electronic Version)
关键词 胃癌干细胞 骨髓来源 标记物 胃癌细胞 分选 胃干细胞 肿瘤干细胞
分类号 R735.2 [医药卫生—肿瘤]
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参考文献30

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共引文献32

消化肿瘤杂志（电子版）
2011年 第4期

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