摘要
目的优化阿魏酸钠胃内漂浮片的制备工艺,并对其体外释药机理进行研究。方法以HPMC K4M为亲水性凝胶骨架,十六醇为助漂剂,NaHCO3为产气剂,采用星点设计-效应面法对处方进行优化,并通过方程拟合探讨释药机制。结果优化得到最优处方,所制得胃内漂浮片均能在1 min内起漂,持续漂浮10 h。结论采用星点设计-效应面法优化的处方预测性良好,并且所制得的胃内漂浮片具有良好的漂浮和控释能力。
OBJECTIVE To optimize the preparation technique of gastric floating tablets of sodium ferulate and study the release mechanism of diammonium glycyrrhizinate release from the tablet.METHODS The gastric floating tablets were prepared with HPMC K4M as gel-matrix,cetyl alcohol as floating-assistant,NaHCO3 as gas-producer.The formulation was optimized by central composite design-response surface methodology.Release mechanism of diammonium glycyrrhizinate from gastric floating tablets was established by equation fitting.RESULTS Optimized formulation region of gastric floating tablets were found.The initial floating time was less than 1 min and the durative floating time was more than 10 h.CONCLUSION Central composite design were successful in optimizing the preparation of tablets with accurate and gastric floating tablets had good floating and sustained release ability.
出处
《中国现代应用药学》
CAS
CSCD
2013年第1期43-47,共5页
Chinese Journal of Modern Applied Pharmacy
关键词
阿魏酸钠
胃内漂浮片
制备
星点设计-效应面法
sodium ferulate
gastric floating tablet
preparation
central composite design-response surface methodology
