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柴胡水提液对大鼠肝CYP450酶含量及其亚型CYP3A、CYP2E1和CYP1A2活性的影响 被引量：1

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摘要 目的:研究柴胡水提物对大鼠细胞色素CYP450酶含量及对亚型CYP3A、CYP2E1和CYP1A2活性的影响。方法:大鼠灌胃给予柴胡水提液7d后取肝脏称重并制备肝微粒体,紫外分光光度法测定肝微粒体细胞色素b5(Cytb5)、P450的含量及CYP3A的活性,高效液相法测定CYP2E1和CYP1A2的活性。结果:与空白对照组比较,柴胡水提液组大鼠肝指数无显著变化,CYP450含量减少但统计学意义(P>0.05),CYP1A2活性极显著降低(P<0.01),CYP2E1活性明显降低(P<0.05)。结论:柴胡水提液降低大鼠肝脏CYP450酶含量并抑制CYP2E1和CYP1A2的活性,由于抑制CYP450酶活性,减少对其他药代谢,提示若柴胡水提液与经CYP2E1和CYP1A2代谢的药物同用,有可能会影响这些药物的临床疗效,临床用药时应慎重考虑。
作者 罗宇静 武佰玲 赵丰雨
机构地区 内蒙古乌兰察布市中心血站 内蒙古通辽市医院 内蒙古医学院附属人民医院
出处 《求医问药（下半月）》 2013年第2期296-297,共2页 Seek Medical and Ask The Medicine
关键词 柴胡 细胞色素P450 CYP3A CYP2E1 CYP1A2
分类号 R285.5 [医药卫生—中药学]
  • 相关文献

参考文献11

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共引文献45

同被引文献13

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求医问药（下半月）
2013年 第2期

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