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急性脑梗死患者血浆NT-proBNP临床意义 被引量:11

Study on the Levels of N-terminal Pro-brain Natriuretic Peptide in Plasma in Patients with Acute cerebral infarction
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摘要 目的探讨急性脑梗死患者血浆N端脑利纳肽前体(NT-proBNP)含量变化的意义。方法将发病48小时内的急性脑梗死患者作为研究对象,根据TOAST分型方法进行病因学分型,所有患者均于入院48小时内行NT-proBNP含量测定,分析NT-proBNP含量与脑梗死亚型的关系。结果 237例急性脑梗死患者中动脉粥样硬化性脑梗死(LAA)64例、小血管闭塞性脑梗死(SAO)60例、心源性脑栓塞(CE)54例和原因不明性脑梗死59例。其中CE组患者血浆NT-proBNP水平明显高于非CE组(P均<0.001),非CE组间差异不显著;入院时神经功能缺损严重者(美国国立卫生研究院卒中量表评分NIHSS≥7分),NT-proBNP水平显著高于入院时神经功能缺损轻微者(NIHSS评分<7分)(P<0.001);死亡患者NT-proBNP水平明显高于存活患者(P<0.001)。结论急性脑梗死尤其是CE患者血浆NT-proBNP水平显著升高,且神经功能缺损越严重,其水平越高;死亡患者NT-proBNP水平显著升高。脑梗死患者早期检测血浆NT-proBNP水平有助于脑梗死病因学亚型诊断,尤其是CE的诊断及有助于病情严重程度及预后的判断。 Objective To investigate the Levels of N-terminal Pro-brain Natriuretic Peptide in Plasma in Patients with Acute cerebral infarction.Methods Patients with acute cerebral infarction enrolled within 48 hours of onset were divided according to the TOAST classification.Plasma NT-proBNP levels were measured in 48 hours after be hospitalized,and the correlation between plasma NT-proBNP levels and differrent subtypes of cerebral infarction were analyzed.Results 237 cases of acute cerebral infarction in patients with large-artery atheroscl-erosis 64 cases,small-artery occlusion 60 cases,cardioembolism54 cases and cryptog-enicc cerebral infarction 59 cases.The plasma NT-proBNP levels in the cardioembo-lism group were significantly higher than those in all the non-cardioembolism groups(all P<0.001),while there were no significant differences in plasma NT-proBNP levels among all the non-CE groups.Patients in serious condition(NIHSS ≥ 7),the NT-proB-NP value is significantly higher than the mild(NIHSS <7)(P<0.001).Conclusion Acute cerebral infarction,particularly the plasma NT-proBNP levels were increased significantly in patients with cardioembolism,the more serious the disease and the higher level.Early detection of plasma NT-proBNP level contribute to etiological classification of cerebral infarction,especially for the diagnosis of cardioembolism,the severity as well as the prognosis of the disease.
出处 《中国实用内科杂志》 CAS CSCD 北大核心 2013年第S1期114-117,共4页 Chinese Journal of Practical Internal Medicine
基金 辽宁省医学高峰建设资助项目
关键词 急性脑梗死 NT-PROBNP Acute cerebral infarction NT-proBNP
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  • 1各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380. 被引量:33029
  • 2Lee SH,Jung JH,Choi SHet al.Determinants of brain natri—ureticpeptide levels in patients with lone atrial fibrillation. Circulation Journal . 2006
  • 3Shibazaki K,Kimura K,Okada Yet al.Plasma brain natriuretic peptide as an independent predictor of in-hospital mortality after acute ischemic stroke. Journal of Internal Medicine . 2009
  • 4DeGraba TJ,Hallenbeck JM,Pettigrew KD,et al.Progression in acute stroke value of the initial NIH stroke scale score on patient stratification in future trials (J). Stroke . 1999
  • 5Panteghini M.Role and important of biochemical marker in clinical cardiology. European Heart Journal . 2004
  • 6M?kikallio,AM,M?kikallio,TH,Korpelainen,JT,Vuoteenaho,O,Tapanainen,JM,Ylitalo,K,Sotaniemi,KA,Huikuri,HV,Myllyl?,V.Natriuretic peptides and mortality after stroke. Stroke . 2005
  • 7Lynch JR,Blessing R,White WD,et al.Novel diagnostic test for acute stroke. Stroke . 2004
  • 8Adams H P,Bendixen B H,Kappelle L J,et al.Classification of subtype of acute ischemic stroke: definitions for use in a multicenter clinical trial. Stroke . 1993
  • 9Montaner J,Molina C,Monasterio J,et al.Matrix metalloproteinase-9 pretreatment level predicts intracranial hemorrhagic complications after thrombolysis in human stroke. Circulation . 2003
  • 10Pemberton CJ,Johnson ML,Yandle TG,et al.Deconvolution analysis of cardiac natriuretic peptides during acute volume overload. Journal of Hypertension . 2000

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  • 1方圻,王士雯,宁田海,朱文玲,张运,邵耕,林传骧,浦寿月,顾复生,徐成斌,戚文航,程显声,戴闺柱.充血性心力衰竭诊断和治疗对策[J].中华心血管病杂志,1995,23(2):83-94. 被引量:361
  • 2阳清伟,刘鸣,张世洪,吴波.依达拉奉治疗急性脑梗死的系统评价[J].中国循证医学杂志,2006,6(1):18-22. 被引量:52
  • 3各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380. 被引量:33029
  • 4Kantan M, Nigro N, Fluri F, et al. Stress hormones predict cere- brovascular e-events after transient ischemic attacks[J]. Neurolo- gy, 2011,76(6): 563.
  • 5Zeeifel C, Katan M, Schuetz P, et al. Copetin is associated with mortality and outcome in patients with acute intracerebral hemor- rhage[J]. BMC Neurology,2010,26(10):1186.
  • 6Lloyd-Jones D. Adams R, Carnethon M, et al. Heart disease and stroke statistics-2009 update: a report from the American Heart Association Statisies Committee and Stroke Statistics Suhcommit- tee[J]. Circulation, 2009,119 : 480.
  • 7Ishikawa J, Ishikawa S, Habutoa T, et al. Cornell product left ven- trieular hypertrophy in electrocardiogram and the risk of strok inageneral population [J]. Hypetension, 2009,53 (10) : 28.
  • 8Januzzi JL Jr, Camargo CA, Anwaruddin S, et al, The Nterminal Pro-BNP investigation of dyspnea in the emergency department (PRIDE) study[J]. Am J Cardiol, 2005,95 (8) : 948.
  • 9Urwyler SA, Sehuetz P, Fluri F, et al. Prognostic Value of Copeptin: One-Year Outcome in Patients With Acute Stroke [J]. Stroke,2010,13 (7) :123.
  • 10James ML, Wang H, Venkatraman T, et al. Brain natriuretic peptide improves longterm functional recovery after acute CNS injury in mice[J]. J Neurotrauma,2010,27(1) :217.

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