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Prevalence of celiac disease in Germany:A prospective follow-up study

Prevalence of celiac disease in Germany:A prospective follow-up study
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摘要 AIM:To determine the prevalence of celiac disease in a randomly selected population sample. METHODS:A total of 2157 subjects (1036 males; 1121 females) participating in a population-based cross-sectional study underwent laboratory testing for tissue transglutaminase and antibodies to immunoglobulin A, endomysium and antigliadin. In a second step, all subjects who had been examined serologically were surveyed using a questionnaire that included questions specific to celiac disease. Subjects with positive antibody titers and those with histories positive for celiac disease then underwent biopsy. At the first follow up, antibody titers were again determined in these subjects and subjects were questioned regarding symptoms specific for celiac disease and disorders associated with celiac disease. The second follow up consisted of a telephone interview with subjects positive for celiac disease.RESULTS:Antibody tests consistent with celiac disease were reported in eight subjects, corresponding to an overall prevalence of 1:270 (8/2157). The prevalence among women was 1:224 and 1:518 in men. Classical symptoms were observed in 62.5% of subjects. Atypical celiac disease was present in 25.0%, and transient celiac disease in 12.5%. False-negative test results were returned in three subjects. This yields a sensitivity and specificity of 62.5% and 50.0%, respectively, for tissue transglutaminase immunoglobulin-A antibody; of 62.5% and 71.4% respectively, for endomysium antibody; and of 62.5% and 71.4%, respectively, for antigliadin antibody.CONCLUSION:The prevalence rate in our collective lies within the middle tertile of comparable studies in Europe. The use of a single antibody test for screening purposes must be called into question. AIM: To determine the prevalence of celiac disease in a randomly selected population sample. METHODS: A total of 2157 subjects (1036 males; 1121 females) participating in a population-based cross-sectional study underwent laboratory testing for tissue transglutaminase and antibodies to immunoglobulin A, endomysium and antigliadin. In a second step, all subjects who had been examined serologically were surveyed using a questionnaire that included questions specific to celiac disease. Subjects with positive antibody titers and those with histories positive for celiac disease then underwent biopsy. At the first follow up, antibody titers were again determined in these subjects and subjects were questioned regarding symptoms specific for celiac disease and disorders associated with celiac disease. The second follow up consisted of a telephone interview with subjects positive for celiac disease. RESULTS: Antibody tests consistent with celiac disease were reported in eight subjects, corresponding to an overall prevalence of 1:270 (8/2157). The prevalence among women was 1:224 and 1:518 in men. Classical symptoms were observed in 62.5% of subjects. Atypical celiac disease was present in 25.0%, and transient celiac disease in 12.5%. False-negative test results were returned in three subjects. This yields a sensitivity and specificity of 62.5% and 50.0%, respectively, for tissue transglutaminase immunoglobulin-A antibody; of 62.5% and 71.4% respectively, for endomysium antibody; and of 62.5% and 71.4%, respectively, for antigliadin antibody. CONCLUSION: The prevalence rate in our collective lies within the middle tertile of comparable studies in Europe. The use of a single antibody test for screening purposes must be called into question.
出处 《World Journal of Gastroenterology》 SCIE CAS 2013年第17期2612-2620,共9页 世界胃肠病学杂志(英文版)
关键词 CROSS-SECTIONAL study CELIAC disease Screening PREVALENCE SEROLOGY Cross-sectional study Celiac disease Screening Prevalence Serology
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  • 1Naiyana Gujral,Hugh J Freeman,Alan BR Thomson.Celiac disease:Prevalence,diagnosis,pathogenesis and treatment[J].World Journal of Gastroenterology,2012,18(42):6036-6059. 被引量:20
  • 2Gudmundur F. Johannsson,Gudjon Kristjansson,Nick Cariglia,Vigfus Thorsteinsson.The Prevalence of Celiac Disease in Blood Donors in Iceland[J].Digestive Diseases and Sciences.2009(2)
  • 3Oberhuber G,Granditsch G,Vogelsang H.The histopathology of coeliac disease: time for a standardized report scheme for pathologists[].European Journal of Gastroenterology and Hepatology.1999
  • 4Robinson J,Waller MJ,Parham P,et al.IMGT/HLA and IMGT/MHC: sequence databases for the study of the major histocompatibility complex[].Nucleic Acids Research.2003
  • 5JM Remes-Troche,MT Ramirez-Iglesias,A Rubio-Tapia,A Alonso-Ramos,A Velazquez,LF Uscanga.Celiac disease could be a frequent disease in Mexico: prevalence of tissue transglutaminase antibody in healthy blood donors[].Journal of Clinical Gastroenterology.2006
  • 6A Fasano,I Berti,T Gerarduzzi,T Not,RB Colletti,S Drago,Y Elitsur,PHR Green,S Guandalini,ID Hill,M Pietzak,A Ventura,M Thorpe,D Kryszak,F Fornaroli,SS Wasserman,JA Murray,K Horvath.Prevalence of celiac disease in at-risk and not-at-risk groups in the United States[].Archives of Internal Medicine.2003
  • 7Oliveira RP,Sdepanian VL,Barreto JA,Cortez AJ,Carvalho FO,Bordin JO,de Camargo Soares MA,da Silva Patrício FR,Kawakami E,de Morais MB,Fagundes-Neto U.High prevalence of celiac disease in Brazilian blood donor volunteers based on screening by IgA antitissue transglutaminase antibody[].European Journal of Gastroenterology and Hepatology.2007
  • 8Hovdenak,N,Hovlid,E,Asknes,L.High prevalence of asymptomatic coeliac disease in Norway: a study of blood donors[].European Journal of Gastroenterology and Hepatology.1999
  • 9Shahbazkhani B,Malekzadeh R,Sotoudeh M,Moghadam KF,Farhadi M,Ansari R,Elahyfar A,Rostami K.High prevalence of coeliac disease in apparently healthy Iranian blood donors[].European Journal of Gastroenterology and Hepatology.2003
  • 10Cook,HB,Burt,MJ,Collett,JA,Whitehead,MR,Frampton,CM,Chapman,BA.Adult celiac disease: prevalence and clinical significance[].Journal of Gastroenterology.2000

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