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Partially hydrolyzed guar gum in pediatric functional abdominal pain 被引量:5

Partially hydrolyzed guar gum in pediatric functional abdominal pain
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摘要 AIM:To assess the effects of partially hydrolyzed guar gum(PHGG) diet supplement in pediatric chronic abdominal pain(CAP) and irritable bowel syndrome(IBS).METHODS:A randomized,double-blind pilot study was performed in sixty children(8-16 years) with functional bowel disorders,such as CAP or IBS,diagnosed according to Rome Ⅲ criteria.All patients underwent ultrasound,blood and stool examinations to rule out any organic disease.Patients were allocated to receive PHGG at dosage of 5 g/d(n = 30) or placebo(fruitjuice n = 30) for 4 wk.The evaluation of the efficacy of fiber supplement included IBS symptom severity score(Birmingham IBS Questionnaire),severity of abdominal pain(Wong-Baker Face Pain Rating Score) and bowel habit(Bristol Stool Scale).Symptom scores were completed at 2,4,and 8 wk.The change from baseline in the symptom severity scale at the end of treatment and at 4 wk follow-up after treatment was the primary endpoint.The secondary endpoint was to evaluate compliance to supplementation with the PHGG in the pediatric population.Differences within groups during the treatment period and follow-up were evaluated by the Wilcoxon signed-rank test.RESULTS:The results of the study were assessed considering some variables,such as frequency and intensity of symptoms with modifications of the bowel habit.Both groups were balanced for baseline characteristics and all patients completed the study.Group A(PHGG group) presented a higher level of efficacy compared to group B(control group),(43% vs 5%,P = 0.025) in reducing clinical symptoms with modification of Birmingham IBS score(median 0 ± 1 vs 4 ± 1,P = 0.025),in intensity of CAP assessed with the Wong-Baker Face Pain Rating Score and in normalization of bowel habit evaluated with the Bristol Stool Scale(40% vs 13.3%,P = 0.025).In IBS subgroups,statistical analysis shown a tendency toward normalization of bowel movements,but there was no difference in the prevalence of improvement in two bowel habit subsets.PHGG was therefore better tolerated without any adverse effects.CONCLUSION:Although the cause of pediatric functional gastrointestinal disorders is not known,the results show that complementary therapy with PHGG may have beneficial effects on symptom control. AIM: To assess the effects of partially hydrolyzed guar gum (PHGG) diet supplement in pediatric chronic abdominal pain (CAP) and irritable bowel syndrome (IBS). METHODS: A randomized, double-blind pilot study was performed in sixty children (8-16 years) with functional bowel disorders, such as CAP or IBS, diagnosed according to Rome III criteria. All patients underwent ultrasound, blood and stool examinations to rule out any organic disease. Patients were allocated to receive PHGG at dosage of 5 g/d (n = 30) or placebo (fruit-juice n = 30) for 4 wk. The evaluation of the efficacy of fiber supplement included IBS symptom severity score (Birmingham IBS Questionnaire), severity of abdominal pain (Wong-Baker Face Pain Rating Score) and bowel habit (Bristol Stool Scale). Symptom scores were completed at 2, 4, and 8 wk. The change from baseline in the symptom severity scale at the end of treatment and at 4 wk follow-up after treatment was the primary endpoint. The secondary endpoint was to evaluate compliance to supplementation with the PHGG in the pediatric population. Differences within groups during the treatment period and follow-up were evaluated by the Wilcoxon signed-rank test. RESULTS: The results of the study were assessed considering some variables, such as frequency and intensity of symptoms with modifications of the bowel habit. Both groups were balanced for baseline characteristics and all patients completed the study. Group A (PHGG group) presented a higher level of efficacy compared to group B (control group), (43% vs 5%, P = 0.025) in reducing clinical symptoms with modification of Birmingham IBS score (median 0 ± 1 vs 4 ± 1, P = 0.025), in intensity of CAP assessed with the Wong-Baker Face Pain Rating Score and in normalization of bowel habit evaluated with the Bristol Stool Scale (40% vs 13.3%, P = 0.025). In IBS subgroups, statistical analysis shown a tendency toward normalization of bowel movements, but there was no difference in the prevalence of improvement in two bowel habit subsets. PHGG was therefore better tolerated without any adverse effects. CONCLUSION: Although the cause of pediatric functional gastrointestinal disorders is not known, the results show that complementary therapy with PHGG may have beneficial effects on symptom control.
机构地区 Pediatric Department
出处 《World Journal of Gastroenterology》 SCIE CAS 2013年第2期235-240,共6页 世界胃肠病学杂志(英文版)
关键词 Functional BOWEL DISORDERS PARTIALLY hydrolyzed GUAR gum PEDIATRIC chronic ABDOMINAL pain Fiber diet Functional bowel disorders Partially hydrolyzed guar gum Pediatric chronic abdominal pain Fiber diet
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参考文献13

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同被引文献30

  • 1Mahnaz Darvish-Damavandi,Shekoufeh Nikfar,Mohammad Abdollahi.A systematic review of effi cacy and tolerability of mebeverine in irritable bowel syndrome[J].World Journal of Gastroenterology,2010,16(5):547-553. 被引量:17
  • 2Andrea Horvath,Piotr Dziechciarz,Hania Szajewska.Glucomannan for abdominal pain-related functional gastrointestinal disorders in children:A randomized trial[J].World Journal of Gastroenterology,2013,19(20):3062-3068. 被引量:3
  • 3R. H. Roest,B. R. Dobbs,B. A. Chapman,B. Batman,L. A. O’Brien,J. A. Leeper,C. R. Hebblethwaite,R. B. Gearry.The low FODMAP diet improves gastrointestinal symptoms in patients with irritable bowel syndrome: a prospective study[J].Int J Clin Pract.2013(9)
  • 4Judith J Korterink,Lize Ockeloen,Marc A Benninga,Merit M Tabbers,Mirrian Hilbink,Judith M Deckers‐Kocken.Probiotics for childhood functional gastrointestinal disorders: a systematic review and meta‐analysis[J].Acta Paediatr.2014(4)
  • 5Siba Prosad Paul,Penny Barnard,Charlotte Bigwood,David C. A. Candy.Challenges in management of irritable bowel syndrome in children[J].Indian Pediatrics.2013(12)
  • 6Marco Daniel Gulewitsch,Judith Müller,Martin Hautzinger,Angelika Anita Schlarb.Brief hypnotherapeutic–behavioral intervention for functional abdominal pain and irritable bowel syndrome in childhood: a randomized controlled trial[J].European Journal of Pediatrics.2013(8)
  • 7M. B. O. Lowén,E. A. Mayer,M. Sj?berg,K. Tillisch,B. Naliboff,J. Labus,P. Lundberg,M. Str?m,M. Engstr?m,S. A. Walter.Effect of hypnotherapy and educational intervention on brain response to visceral stimulus in the irritable bowel syndrome[J].Aliment Pharmacol Ther.2013(12)
  • 8Horvath, Andrea,Dziechciarz, Piotr,Szajewska, Hania.Systematic Review of Randomized Controlled Trials: Fiber Supplements for Abdominal Pain-Related Functional Gastrointestinal Disorders in Childhood[J].Annals of Nutrition & Metabolism.2012(2)
  • 9Monica Jarrett,Margaret Heitkemper,Danita Czyzewski,Lonnie Zeltzer,Robert J. Shulman.Autonomic Nervous System Function in Young Children With Functional Abdominal Pain or Irritable Bowel Syndrome[J].Journal of Pain.2012(5)
  • 10Kara Bradford,Wendy Shih,Elizabeth J. Videlock,Angela P. Presson,Bruce D. Naliboff,Emeran A. Mayer,Lin Chang.Association Between Early Adverse Life Events and Irritable Bowel Syndrome[J].Clinical Gastroenterology and Hepatology.2012(4)

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