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Inhibiting effect of CaMK Ⅱ N up-regulation on leukemia cells growth and its mechanism

Inhibiting effect of CaMK Ⅱ N up-regulation on leukemia cells growth and its mechanism
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摘要 Objective To investigate the inhibitory effects of CaMKⅡN on acute myeloid leukemia cell line HL-60to explore a novel therapeutic target of leukemia.Methods Human CaMKⅡN gene expression vector pcDNA3.1/hCaMKⅡN or empty vector pcDNA3.1/myc-His(-)B was transfected into HL-60 cells by Lipofectamine2000.Human CaMKⅡN proteins of transfected cells were detected by Westem blot.Cell proliferation affected by human CaMKⅡN was determined by MTT.Colonyforming assay was performed by soft
作者 侯军
机构地区 Dept Hematol
出处 《China Medical Abstracts(Internal Medicine)》 2014年第1期54-54,共1页 中国医学文摘(内科学分册(英文版)
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