摘要
副猪嗜血杆菌是当前世界养猪业中最主要的细菌性病原体之一,感染后临床表现以格拉泽病为典型特征,严重威胁着猪群健康,应用层面的防治工作仍存在很多问题。近年来,该细菌毒力因子与宿主免疫应答等相关研究取得了很大进步,但基础层面宿主-病原互作的分子机制仍不清楚。基于不同猪对该细菌存在遗传抗性差异,随着猪基因组科学技术的飞速发展,越来越多的国内外学者正寄希望于分子抗病育种途径以从根本上解决细菌感染。为此,本文结合作者所在课题组的以往工作通过综述现有高通量数据初步提出了宿主免疫应答的分子模型,重点探讨巨噬细胞活化对细菌感染或宿主保护性免疫应答可能造成的影响,围绕其中关键的分子调控进行了较为深入的分析,旨在为将来发掘具有应用价值的候选基因素材/分子标记提供借鉴。最后,本综述就下一步相关工作的开展提出了几点思考。
Haemophilus parasuis(HPS)is one of the main virulent bacteria that threating the pig industry worldwide.HPS infection typically causes serious inflammations,namely Glsser’s disease.But there are still many troubles in disease prevention and control.Though much progress has been made in the basic research fields of bacterial virulent factors and host immune responses(IR)recently,the mechanisms of host-bacillus interaction are largely unknown.As the different susceptibilities in pigs exist,genomic selection based on molecular breeding strategy will receiving increasing attention from scientists and commercial breeders.Here,some high through-out data from our and other labs are reviewed in brief and the model for the host IR is proposed.We hypothesize that the activation of macrophage during the early stage of IR may play pivotal roles in determining bacillus escape and/or host protective IRs.In addition,key molecules and pathways involved in the IR of macrophage are discussed,which we hope will be helpful for the marker identifications in objectives of molecular breeding.Still,there is much work to be done and some suggestions are proposed in the article.
出处
《畜牧兽医学报》
CAS
CSCD
北大核心
2015年第1期1-11,共11页
ACTA VETERINARIA ET ZOOTECHNICA SINICA
基金
武汉市科技局应用基础研究计划项目(2013020501010178)
湖北省自然科学基金(2013CFB324)
国家自然科学基金(31301939)
关键词
猪
育种
副猪嗜血杆菌
免疫应答
巨噬细胞
pig
breeding
Haemophilus parasuis
immune response
macrophage
