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洛汀新与缬沙坦对老年急性心肌梗死患者心室重塑及心功能的影响 被引量：17

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摘要 目的比较洛汀新与缬沙坦对老年急性心肌梗死(AMI)患者心功能的影响。方法选择AMI患者100例,随机分为两组,其中缬沙坦组50例、洛汀新组50例,两组均行AMI常规治疗,缬沙坦组加用缬沙坦80 mg/d、洛汀新组加用洛汀新10 mg/d,疗程3个月。比较两组患者治疗前后临床症状、心功能及心室重塑指标变化。结果两组间患者治疗后16 w临床症状评分及心功能NYHA分级与治疗前比较有差异(P<0.05);两组间间患者治疗后16 w临床症状评分及心功能NYHA分级比较有差异(P<0.05);两组间患者治疗16 w后左室收缩期末容积(LVESV)、左室舒张期末容积(LVEDV)、左室射血分数(LVEF)与治疗前比较有差异(P<0.05);两组间患者治疗后16 w LVESV、LVEDV、LVEF比较有差异(P<0.05);两组患者治疗16 w后舒张末期室间隔厚度(IVST)、左室后壁厚度(LVPWT)、左室心肌重量指数(LVMI)与治疗前比较有差异(P<0.05);两组患者治疗后16 w IVST、LVPWT、LVMI比较有差异(P<0.05);洛汀新组患者发生中度以上心力衰竭4例,缬沙坦组患者发生中度以上心力衰竭12例,两组比较有差异(P<0.05)。结论洛汀新和缬沙坦均能明显改善左室功能,阻抑左室重塑过程,提高左室收缩的同步性;而洛汀新的效果优于缬沙坦。
作者 李春慧
机构地区 沈阳医学院附属中心医院药剂科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2015年第1期82-84,共3页 Chinese Journal of Gerontology
关键词 洛汀新 缬沙坦 急性心肌梗死 左室重塑 心功能
分类号 R542.22 [医药卫生—心血管疾病]
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参考文献10

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二级参考文献63

共引文献17

同被引文献138

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引证文献17

二级引证文献89

中国老年学杂志
2015年 第1期

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