摘要
血管钙化是指羟磷灰石矿物质沉积于血管系统的病理过程,临床多见于动脉粥样硬化的斑块、糖尿病、衰老及慢性肾功能衰竭、尿毒症的血管及心脏瓣膜,目前尚缺乏有效的治疗方法。多种机制参与了血管钙化的发生,包括成骨细胞和破骨细胞的标志分子、血管钙化抑制因子、基质囊泡、微核糖核苷酸、钙磷稳态失衡以及血管旁/自分泌活性因子的功能紊乱、氧化应激、内质网应激以及自噬等均参与血管钙化的发生发展。关注和加强血管钙化的基础研究,促进血管钙化的临床转化研究对于揭示血管钙化的发病机制和血管钙化相关疾病的防治具有重要意义。
Vascular calcification is a pathologic process of calcium-phosphate deposition in the vessel wall that has been associated with aging,atherosclerotic plaque,cardiovascular disease,diabetes mellitus,chronic kidney disease,uremic arteriole and cardiac valves. However,there have not effective treatments for vascular calcification. Several of the key mechanisms involve in vascular calcification,such as markers of osteoblast and osteoclast,inhibitors of vascular calcification,matrix vesicles,micro ribonucleic acid,inbalance of calcium and phosphate homeostasis,disorder of vascular paracrine or autocrine factor,oxidant stress and endoplasmic reticulum stress. Focus on basic and translational medicine of vessel calcification and,thereby,reveal mechanism of vascular calcification and reduce cardiovascular risk.
出处
《中国动脉硬化杂志》
CAS
北大核心
2015年第5期433-436,共4页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金资助(91339203
81270407)
关键词
血管钙化
机制
疾病
Vascular Calcification
Mechanism
Disease
