摘要
血管钙化是糖尿病患者的一个常见并发症,包括血管内膜钙化和中膜钙化,呈进展性,是糖尿病患者心血管疾病及全因死亡的预测因子。糖尿病血管钙化是多种促进和抑制钙化的因素参与的细胞介导的主动调节过程,高血糖、胰岛素抵抗、肾脏疾病、炎症、骨相关蛋白表达异常等多种因素与其相关。对于糖尿病血管钙化,目前尚无有效的治疗手段,及时评价和控制血管钙化的危险因素,进行合理的预防性治疗非常重要。
Vascular calcification is a common complication in diabetic patients,which includes intimal calcification and medial calcification. Vascular calcification is usually progressive and a predictor of cardiovascular disease and allcause mortality in these patients. Vascular calcification in diabetics is an active,highly regulated,cell-mediated process involved in various promotors and inhibitors. Various factors play a significant role in vascular calcification,including hyperglycemia,insulin resistance,kidney disease,inflammation,abnormal bone-associated protein,etc. There is no effective treatment for vascular calcification in diabetics at present. It is very important to evaluate and control risk factors of vascular calcification and provide preventive therapy for patients with diabetes.
出处
《中国动脉硬化杂志》
CAS
北大核心
2015年第5期458-463,共6页
Chinese Journal of Arteriosclerosis
基金
北京大学人民医院研究与发展基金(ROB2013-13)
关键词
糖尿病
血管钙化
心血管疾病
Diabetes
Vascular Calcification
Cardiovascular Disease
