期刊文献+

路易斯酸催化烯基醚与胺缩醛和醇反应合成β-氨基缩醛(英文)

Lewis acid-Catalyzed Difunctionalization of Enol Ethers with Aminals and Alcohols to β-Amino Acetals
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摘要 发展了一种路易斯酸催化的烯基醚,胺缩醛和醇的3组分反应一步合成β-氨基缩醛的方法.这一合成过程使用廉价的氯化镍作路易斯酸催化剂,反应条件温和,操作方便,得到的目标产物收率最高可达91%. We have developed a Lewis acid catalyzed three-component reaction of enol ethers,aminals and alcohols. The reaction system can provide a facile one-step access to β-amino acetals from simple aminals,enol ethers and alcohols under mild conditions.
出处 《分子催化》 EI CAS CSCD 北大核心 2015年第2期103-110,共8页 Journal of Molecular Catalysis(China)
基金 Foundation:21222203,21172226 and 21133011
关键词 路易斯酸 烯基醚 胺缩醛 β-氨基缩醛 3组分反应 Lewis acid enol ethers aminals alcohols β-amino acetals three-component reaction.
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参考文献17

  • 1胡建华,谢银君,黄汉民.水促进的三组分PBM反应合成三级胺(英文)[J].分子催化,2014,28(3):197-203. 被引量:1
  • 2洪灵芬,孙楠,任鸿,莫卫民,胡宝祥,沈振陆,胡信全.钯催化芳基溴代物和氨基乙醛缩二乙醇的偶联反应研究[J].分子催化,2011,25(6):489-495. 被引量:1
  • 3Jianhua Hu,Yinjun Xie,Hanmin Huang.Palladium‐Catalyzed Insertion of an Allene into an Aminal: Aminomethylamination of Allenes by C?N Bond Activation<link href="#nss"/>[J]. Angew. Chem. Int. Ed. . 2014 (28)
  • 4Yanping Zhou,Yinjun Xie,Lei Yang,Pan Xie,Hanmin Huang.Copper-Catalyzed Aerobic Oxidative Amination of Arylboronic Acid with Aminal under Base-Free Conditions[J]. Tetrahedron Letters . 2013 (21)
  • 5A. S. Gazizov,A. R. Burilov,M. A. Pudovik,A. I. Konovalov.Reaction of B-aminosubstituted acetals and aldehydes with 2-methylresorcinol[J]. Russian Journal of General Chemistry . 2008 (12)
  • 6Simon B. Davies,M.Anthony McKervey.Convenient in situ synthesis of nonracemic N -protected β-amino aldehydes from β-amino acids. Applications in Wittig reactions and heterocycle synthesis[J]. Tetrahedron Letters . 1999 (6)
  • 7Franklin A Davis,Joanna M Szewczyk.Synthesis and applications of nonracemic β-amino aldehydes to the asymmetric synthesis of piperdines: (+)-dihydropinidine[J]. Tetrahedron Letters . 1998 (33)
  • 8NazaréM,Waldmann H.Synthesis of the 9S,18R diastereomer of cyclamenol A. Angewandte Chemie International Edition . 2000
  • 9Carlos J. Saavedra,Alicia Boto,Rosendo Hernández.Preparation of modified peptides: direct conversion of α-amino acids into β-amino aldehydes. Organic and Biomolecular Chemistry . 2012
  • 10Masahiro Terada,Yasunori Toda.Double Bond Isomerization/Enantioselective Aza-Petasis?Ferrier Rearrangement Sequence as an Efficient Entry to Anti- and Enantioenriched β-Amino Aldehydes. Journal of the American Chemical Society . 2009

二级参考文献14

  • 1HuYuefei(胡跃飞),LinGuoqiang(林国强).Metal CatalyzedReaction(金属催化反应)[M],Beijing:ChemicalIndustryPress(北京化学工业出版社),2008,5.
  • 2HartwigJF.Acc.Chem.Res.[J],2008,41:1534-1544.
  • 3TorborgC,BellerM.Adv.Synth.Catal.[J],2009,351:3027-3043.
  • 4SurryDS,BuchwaldSL.Angew.Chem.,Int.Ed.[J],2008,47:6338-6361.
  • 5HortonDA,BourneGT,SmytheML.Chem.Rev.[J].2003,103:893-390.
  • 6ForsBP,BuchwaldSL.J.Am.Chem.Soc.[J],2010,132:15914-15917.
  • 7SurryDS,BuchwaldSL.Chem.Sci.[J],2011,2:27-50.
  • 8SundbergJR,LaurinoJP.J.Org.Chem.[J],1984,49:249-254.
  • 9YamakawaT,KagechikaH,KawachiE,etal.J.Med.Chem.[J],1990,33:1437-1443.
  • 10KamerPC,vanLeewenPNM,ReekJNH.Acc.Chem.Res.[J],2001,34:895-904.

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