期刊文献+

caspase-3、bcl-2基因及Ki-67在胃癌前病变中的表达及意义 被引量:2

Expressions of caspase-3,bcl-2 and Ki-67 in precancerous lesions of the stomach
下载PDF
导出
摘要 目的 探讨caspase 3、bcl 2基因及Ki 6 7在胃癌前病变不同转归中的作用。方法 采用免疫组化SP法检测 6 0例胃癌患者胃癌及癌前病变组织标本 [胃粘膜中度以上肠上皮化生和 (或 )异型增生 ]及其正常胃粘膜组织标本的Ki 6 7、caspase 3、bcl 2的表达。 结果 ①Ki 6 7、caspase 3、bcl 2标记指数在癌前病变组表达明显高于正常组 ,差异有显著意义 (P <0 0 1) ;②caspase 3、bcl 2和Ki 6 7表达在胃癌组织均显著高于癌变前组织 (P <0 0 1)。结论 在胃癌发生发展过程中 ,caspase 3、bcl 2蛋白表达起重要作用 。 Objective To study the role of biological marks(caspase-3,bcl-2 and Ki-67) in precancerous lesions of the stomach.Methods Immunohistochemical method(LSAB) was used to assess the expressions of caspase-3,bcl-2 and Ki-67 in specimens from patients with and without gastric cancer.Results (1)Ki-67 expression in precancerous group was higher than that in control group(P<0.01).(2)caspase-3,bcl-2 and Ki-67 expressions in cancerous tissue were higher than those in precancerous group and non-cancerous group(P<0.01).Conclusion The expressions of caspase-3 and bcl-2 significantly influenced the development of intestinal-type gastric carcinoma,and the proliferating activity had significantly increased before the occurence of gastric cancinoma.
出处 《中国临床保健杂志》 CAS 2004年第3期198-200,共3页 Chinese Journal of Clinical Healthcare
关键词 胃肿瘤 癌前状态 基因caspase-3 基因BCL-2 KI-67 Stomach neoplasms Precancerous conditions Gene caspase-3 Gene bcl-2 Ki-67
  • 相关文献

参考文献6

  • 1[1]Tahara E.Genetic alterations in human gastrointestinal cancers.The application to molecular diagnosis[J].Cancer,1995,75:1410-1417.
  • 2张伟.人类caspase家族蛋白酶与凋亡[J].国外医学(遗传学分册),1999,22(6):290-293. 被引量:36
  • 3[3]Droin N,Dubrez L,Eymin B,et al.Upregulantion of CASP genes in human tumor cells undergoing etoposide-induceapoptosis[J].Oncogene,1998,16(2):2885-2894.
  • 4[4]Miyashita T,Krajewski S,Krajewska M,et al.Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo[J].Oncogene,1994,9:1799-1805.
  • 5[5]Lauwers GY,Scott GV,Hendricks J,et al.Immunohistochemical evidence of aberra nt bcl-2 protein expression in gastric epithelial dysplasia[J].Cancer,1994,73:2900-2904.
  • 6江继发,魏海明.检测肿瘤转移指标的临床意义[J].国外医学(肿瘤学分册),1998,25(2):82-84. 被引量:7

二级参考文献1

  • 1U. Leonhardt,U. Ritzel,M. Ottleben,A. Vignoli,G. Ramadori. Detection of circulating albumin-mRNA by RT-PCR does not indicate metastasizing hepatocellular carcinoma[J] 1997,Langenbecks Archiv für Chirurgie(2):83~86

共引文献41

同被引文献26

引证文献2

二级引证文献19

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部