摘要
目的 :研究尿液西司他汀C(Cys-C)与肾小管损害的关系。 方法 :应用酶联免疫吸附试验 (ELISA)尿液Cys -C ,同时用放射免疫分析 (RIA)测定尿液 β2 微球蛋白 (β2 -m)、α1微球蛋白 (α1-m) ,用Jaffe速率法测定尿液肌酐 (Cr) ,计算尿液Cys-C与肌酐比值 (C/Cr)。结果 :有肾小管损害病人尿液C/Cr水平显著增高(P <0 0 1)且与 β2 -m、α1-m有正相关关系 (r =0 .312 5 ;r =0 .2 839) ,并有显著性意义 (P <0 0 1)。结论 :尿液C/Cr是早期发现肾小管损害的灵敏指标 ,能反映肾小管损害程度。
Objective To investigate the relationship between urinary Cystatin C content and severity of renal tubular dysfunction. Methods Contents of urinary cystatin C (with ELISA)、 urinary β 2-m and α 1-m(with RIA)、 urinary creatinine (with Jaffe’s method) and cystatin C creatinine ratio were determined in 98 controls, 77 subjects with low urinary β 2-m(<1mg/L), 75 subjects with high urinary β 2-m and 66 patients with chronic renal failive. Results The values of urinary cystatin C/creatinine ratio in patients with renal tubular dysfunction were significantly higher than those in controls (P<0.01). There was a marked positive correlation between urinary cystatin C/Creatinine ratio and levels of urinary β 2-m and α 1-m in patients with renal tubular dysfunction (r=0.3125; r=0.2839, all P<0.01). Conclusion Urinary cystatin C/creatinine ratio is a sensitive indicator of renal tubular dysfunction and can reflect the severity of the disease.
出处
《放射免疫学杂志》
CAS
2004年第3期232-233,共2页
Journal of Radioimmanology
