摘要
目的 观察角质细胞生长因子 2 (KGF 2 )对实验性兔角膜中央碱烧伤的治疗效果。方法 将 2 4只兔角膜碱烧伤眼随机分成 4组 ,用KGF 2滴眼液治疗 ,以后行荧光素染色裂隙灯显微镜照相 ,照片经计算机图象系统分析 ,角膜切片HE染色 ,光镜检查。结果 10 0 μg/mLKGF 2角膜上皮愈合率最高 ,且与剂量呈依赖性 ,各治疗组与对照组之间差异均有显著性意义 ,P <0 0 5。结论 KGF
Objective To evaluate the curative effect of KGF-2 on the alkali-injured rabbit eye. Methods Twenty-four New Zealand rabbits alkali burned corneas wounds were produced.Four groups were divided and treated with KGF-2 solution (1,50,100 μg/ml) and PBS solution.The injured eyes were photographed after the fluoresent staining with a slit lamp and the pictures wered dealt with computer-aided picture analysis system.The morphologic exanination of corneas was made.Results KGF-2 at a dosage ranging from 1 μg/ml to 100 μg/ml could enhanced the cornea wound healing process than the control groups (P<0.05).Conclusion These results suggested that KGF-2 could accelerate the healing of alkali burned cornea.
出处
《眼外伤职业眼病杂志》
北大核心
2004年第6期361-365,共5页
Journal of Injuries and Occupational Diseases of the Eye with Ophthalmic Surgeries
基金
国家自然科学基金 (39870 80 1 )
"2 1 1"工程基金 (980 0 7)
广东省自然科学基金 (980 1 1 )
广东省社会发展攻关项目 (2 0 0 3A30 2 0 30 2 )资助
广州市科技攻关计划-科技攻关引导项目部分资助
