摘要
目的 探讨卵巢血管紧张素II(AngII)及其受体 (AT1、AT2 )在人卵巢的表达与分布。 方法 免疫组化法检测33份人卵巢组织标本中AngII及其受体AT1、AT2的表达与分布。 结果 AngII及受体AT1、AT2在卵巢的分布基本一致 ,三者在卵母细胞均有表达 ,大卵泡尤其是排卵前卵泡的颗粒细胞含量丰富 ,卵泡膜细胞几无表达 ;颗粒黄体细胞与膜黄体细胞三者含量均丰富 ,并伴随黄体退化而消失。 结论 AngII及其受体可在人卵巢局部生成 ,并存在于同一种细胞内 ,提示它们可能以自分泌方式参与卵巢功能的调节。
Objective: To investigate the distribution and intensity of angiotensin II (Ang II) and its two types of receptors (AT1 and AT2) in the human ovary.Methods:The distribution and intensity of Ang II and its receptors (AT1 and AT2) in 33 human ovarian samples were measured by immunohistochemistry.Results: The distribution of Ang II and its receptors (AT1 and AT2) in the ovary was in a similar pattern. They were located in the granulosa cell layer of the large follicles and in the two types of cells of corpus luteum in a certain amount detected by immunohistochemistry,and faded away with luteum degeneration.Conclusion: Ang II and its receptors (AT1 and AT2) can be produced locally in human ovarian tissue. The co-expression of Ang II and its receptors in the same cells suggests that they could regulate the ovarian function with an autocrine pattern.
出处
《生殖医学杂志》
CAS
2004年第3期146-149,共4页
Journal of Reproductive Medicine
