摘要
目的 探讨脉冲振荡技术 (IOS)阻力和流速依赖 (dR/dV′)对气道病变的诊断价值。方法 采用德国IOS肺功能仪对正常、吸烟和慢性阻塞性肺病 (COPD)共 72例进行阻力 /流速依赖 (dR/dV′)和FVC曲线有关指标检测、比较 ,并做回归分析。结果 dR/dV′正常组分别与吸烟组和COPD组之间均有显著差异 (P <0 0 1) ,但COPD组与吸烟组无差异 (P >0 0 5 ) ;dR/dV′与FEV1、V50 和V2 5分别呈显著负相关 (P <0 0 0 1) ;采用“正常组的均值+1 6 5标准差”作为异常判别标准对正常组的误检率为 4 17% ,对吸烟组和COPD组共 4 8例阳性率为 4 1 6 7%。结论 dR/dV′可以作为判断有无气道阻塞比较特异的指标 ,但可能无法反映病情的严重程度。
Objective To assess the diagnostic value of the flow velocity gradients of resistance(dR/dV') in treating airway obstruction using impluse oscillometry. Methods The dR/dV' value, FEV 1, V 50, and V 25 were measured and compared using 72 cases including control, smoking and COPD groups. The dR/dV' values were regressed with FEV 1, V 50 and V 25, respectively. Results Significantly different dR/dV' values were found between control and smoking groups and between control and COPD groups, but not between smoking and COPD groups. Significantly negative correlation was found between dR/dV' and FEV 1, and similarly, between dR/dV' and V 50 and between dR/dV' and V 25. If the dR/dV' value exceeded x ±1.65s it was considered abnormal, and the misdiagnosis rate was 4.17% in the normal group, while the positive rate reached 41.67% in 48 cases (smoking and COPD groups). Conclusion The dR/dV' is considered an index for detecting airway obstruction, but is not accurate in reflecting the severity of the disease.
出处
《医用生物力学》
EI
CAS
CSCD
2004年第2期117-119,共3页
Journal of Medical Biomechanics
关键词
阻力流速依赖
脉冲振荡
气道病变
诊断
dR/dV′
Impluse oscillometry
Airway obstruction
Diagnosis
