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咪唑[4,5-b]并吡啶类化合物的合成 被引量:3

Synthesis of Imidazo[4,5-b] Pyridine Derivatives
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摘要 AIM:To search for new inhibitors with excellent activity and stability to (H ++K +)ATPase.METHOD:Beginning with 2-amino-6-chloro-3-nitropyridine,the title compounds were obtained by substitutioin,cyclization and oxidation.RESULT:Five new compounds were synthesized and the structure of the title compounds was identified by IR, 1HNMR and ESI-MS.Activity and stability of the five new compounds are on searching. AIM:To search for new inhibitors with excellent activity and stability to (H ++K +)ATPase.METHOD:Beginning with 2-amino-6-chloro-3-nitropyridine,the title compounds were obtained by substitutioin,cyclization and oxidation.RESULT:Five new compounds were synthesized and the structure of the title compounds was identified by IR, 1HNMR and ESI-MS.Activity and stability of the five new compounds are on searching.
出处 《中国药科大学学报》 CAS CSCD 北大核心 2004年第3期280-282,共3页 Journal of China Pharmaceutical University
关键词 H^+/K^+-ATP酶抑制剂 2-氨基-6-氯-3-硝基吡啶 合成 Inhibitor of (H++K+)ATPase 2-Amino-6-chloro-3-nitropyridine Synthesis
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  • 1Georg Rainer,Konstanz. Fluoroalroxy substituted benzimidazoles useful as gastric acid secretion inhibitors[P]. United States Patent:US4555518,1985-11-26.
  • 2Naoto Matsuishi,Kawaguchi, Haruki Takeda, et al.Imidazo[4,5-b]pyridine compounds and pharmaceutical compositions containing same[P]. United States Patent:US4808596,1989-2-28.
  • 3Marian Wozniak,Andrzej Baranski,Barbara Szpakiewicz.Regioselectivity of the amination of some 3-nitropyridines by liquide ammonia/potassiom pormangunate[J]. Liebigs Ann Chem,1991,875-878.
  • 4JA Vanallan,BD Deacon.2-Mercaptobenzimidazole[J]. Organic Syntheses,1963(CV4),569-570.

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