摘要
作者用核团内微最注射和行为测痛法,研究了大鼠监斑(LC)内注射催产素(OT)或催产素抗血清(AOTS)对痛阈和吗啡镇痛的影响。结果表明蓝斑内注射OT可使大鼠痛阈(PT)明显提高,且镇痛作用随OT的剂量增加而增强;而注射AOTS则使痛阈降低。蓝斑内注射催产素可加强皮下注射吗啡的镇痛作用,而注射AOTS则对吗啡镇痛作用有拮抗作用。提示OT的镇痛和对吗啡镇痛的协同作用可能与蓝斑有密切关系。
The microinjection of brain nuclei and potassium iontophresis induced tail flick were used to investigate the effect of injecting oxytocin (OT) or anti-oxytocin serum (AOTS) into locus ceruleus (LC) on the pain threshold (PT) and morphine analgesia. The result showed that OT injection into LC could enhance PT, while ATOS injection could reduce PT. The OT injection could strengthen morphine analgesia, but AOTS injection could antagonize this action. These results suggest that the OT analgesia and OT-enhanced morphine analgesia were related with the locus ceruleus.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1993年第6期527-530,共4页
Academic Journal of Second Military Medical University
基金
国家自然科学基金(39070336)
关键词
催产素
蓝斑
吗啡
止痛
oxytocm
anti-oxytocin serum
locus ceruleus
morphine
pain threshold
animal
rats
