摘要
为了解 1 999～ 2 0 0 3年临床分离金黄色葡萄球菌耐药性的变迁情况 ,采用K B方法和微量肉汤稀释法 ,对 1 999年 1月至 2 0 0 3年 1 2月临床分离的 42 3株金黄色葡萄球菌进行药敏试验 ;耐药率的显著性比较采用x2 检验。结果显示 ,1 999～ 2 0 0 3年从临床送检标本中共分离出金黄色葡萄球菌 42 3株。 2 0 0 2～ 2 0 0 3年MRSA的分离率为 1 9.7% (2 9/ 1 47)有增加趋势 ,高于 1 999～ 2 0 0 0年度分离率 1 7.5 % (3 3 / 1 89)。在 2 0 0 2～2 0 0 3年间MSSA对头孢吡肟、环丙沙星、左旋氧氟沙星、复方新诺明、氯霉素和庆大霉素的耐药率分别为0 .0 % ,4.6% ,2 .3 % ,1 .3 % ,6.8%和 2 1 .8%。而对青霉素、红霉素和克林霉素耐药率较高 ,为 5 1 .9% ,70 .4%和 41 .3 %。与 1 999～ 2 0 0 0年比较 ,MSSA对青霉素G、环丙沙星、四环素和复方新诺明的耐药率明显下降 ,p <0 .0 5。 5a间未发现耐万古霉素和替考拉宁菌株。 1 999～ 2 0 0 3年MRSA发生率有增加趋势。耐药性监测有助于遏制抗菌药物的耐药问题。
To investigate the drug-resistance dynamics of clinically isolated Staphylococcus aureus during 1999 and 2003.Antimicrobial susceptibility of 423 clinical isolates from 1999 to 2003 was tested by K-B method and broth microdilution method. x+2 was made to identify the significance of prevalence of drug-resitant Staphylococcus aureu.423 strains of Staphylococcus aureus were isolated from the First Affiliated Hospital of China Medical University during 1999～2003. The prevalence of methicillin-resistant Staphylococcus aureus (MRSA) was 19.7%(29/147) during 2002～2003, which is higher than that during 1999～2000.The resistant rates of methicillin sensitive.
出处
《微生物学杂志》
CAS
CSCD
2004年第4期53-55,共3页
Journal of Microbiology
关键词
金黄色葡萄球菌
耐药
Staphylococcus aureu,Drug-resistance.
