摘要
目的 :探讨G CSF联合LD AA方案治疗高危组急性髓细胞性白血病 (Acutemyelocyticleukemia ,AML)的临床疗效。方法 :5例高危组AML患者采用G CSF联合小剂量阿克拉霉素和阿糖胞苷 (LD AA)治疗 ,并观察其毒副作用。结果 :5例患者中 ,4例达到CR ,PR1例 ,总有效率为 1 0 0 % (5 / 5 )。 2例有轻度的骨髓抑制作用 ,1例有一过性的心脏损害 ,2例有骨痛表现。结论 :G CSF联合LD AA方案治疗高危组AML不仅有较高的临床缓解率 ,而且毒副作用少 ,是一种较好的治疗方法。
Objective:To explore the therapeutic method of.high risk acute myelogenous leukemia.Methods:Five patients with high risk acute myeloid leukemia(AML)were treated by low dose aciacinomycin and cytosine arabinoside(LD AA)in combined with granulocyte colony stimulating factor(G CSF).Clinical effects and ill sides of the protocol were observated.Results:4 out of 5 patients with high risk AML achieved complete remission(CR)and 1 achieved partial remission.The total efficiency was 100%.2 patients were of low grade of bone marrow depression.2 had ligh bone pain and 1 had cardiopathic damage.Conclusions:For high risk acute myeloid leukemia,the protocol of LD AA in combined with G CSF was of higher CR rate and less ill sides.It may be regarded as an better choice for high risk AML.
出处
《实用临床医学（江西）》
CAS
2004年第4期7-9,共3页
Practical Clinical Medicine
