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错配修复缺陷,微卫星不稳定与胃癌 被引量：3

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摘要 人类错配修复系统可以识别并纠正DNA复制过程中出现的错误.错配修复系统缺陷使这些错误往往无法消除,导致恶性肿瘤的发生.患者经常表现出微卫星不稳定性.目前发现与人类恶性肿瘤发病有关的错配修复基因包括hMSH2、hMSH3、hMSH6、hMLH1及hMLH3.这些基因的突变在遗传性非息肉病性结直肠癌中的作用已得到广泛证实.临床上很大一部分胃癌患者表现出微卫星不稳定性,提示错配修复缺陷在胃癌的发病中亦起到重要作用.众多的研究发现错配修复基因的突变在胃癌中并不常见,而由于hMLH1启动子甲基化及失活所引起的错配修复缺陷成为胃癌发病机制中—条重要途径.这些患者常具有微卫星不稳定性及独特的临床特征.
作者 赵成海
机构地区 中国医科大学病理生理教研室
出处 《世界华人消化杂志》 CAS 2004年第6期1384-1388,共5页 World Chinese Journal of Digestology
关键词 错配修复系统 错配修复缺陷 微卫星不稳定性 胃癌 肿瘤 基因序列
分类号 R735.2 [医药卫生—肿瘤]
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世界华人消化杂志
2004年 第6期

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