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一种有效的甘露糖3,6位选择性保护和脱保护的新方法

The Preparation of 3-and 6-Modified Mannose/Altrose as Building Blocks for Saccharide Synthesis
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摘要 文章报道了一种有效的甘露糖3,6位选择性保护和脱保护的新方法,该方法具有条件温和,选择性好,收率高等优点。这对于用甘露糖作为糖基给体或是糖基受体,以其合成在3,6位用不同糖基修饰支化的寡糖有着非常重要的意义。由于3,6位支化的甘露糖在生物糖蛋白中有着很高的表达。合成这类寡糖对于理解它们在生物体中的作用提供了先决条件。 A highly efficient method to get some 3- or 6-modified mannose/altrose derivatives as both donor and acceptor for oligosaccharide synthesis was described. All the compounds with the combination for 3-and/or 6-hydroxyl protection and/or activation (including the configuration conversion of 3-carbon atom) were obtained exclusively.
作者 解荡 成昌梅 王霞瑜 郭晓强 赵玉芬
机构地区 湘潭大学高分子科学与材料研究所 清华大学生命有机磷及化学生物学教育部重点实验室
出处 《精细化工中间体》 CAS 2004年第3期13-15,24,共4页 Fine Chemical Intermediates
关键词 选择性 甘露糖 保护 脱保护 寡糖 selection mannose protection deportection oligosaccharide
分类号 TQ629.13 [化学工程—精细化工]
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参考文献11

  • 1Wei W, Fanzuo K. Highly regio-and stereoselective synthesis of mannose-containing oligosaccharides with acetobromo sugar as the donors and partially protected mannose derivatives as the acceptors via sugar orthoester intermediates [ J ]. Angew Chem Int Ed.1999, 38: 1247～1250.
  • 2Dipak K Mandal, Lokesh B, Seymour H K, et al. Studies of binding specificity of concanavaling A. Nature of the Extended Binding Site for Asparagine-Linked Cabohydrates[J]. Biochemistry 1994, 33:1157～1162.
  • 3Brent A Williams, Mary CC, Eric JT. Energetics of lectin-carbohydrate bnding [J]. The Journal of Biological Chemistry 1992,267: 22907 ～ 22911.
  • 4Dipak K Mandal, C Fred Brewer. Differences in the binding affinities of dimeric concanavalin A ( Including Acetyl and Succinyl Derivatives) and tetrameric concanavalin A with large oligomannosetype glycopeptides [J ]. Biochemistry, 1993, 32: 5116～ 5120.
  • 5Hadar F, Daniel AM, Kurt D, William IW. Structural basis for selective recognition of oligosaccharides by DC - SIGN and DCSIGNR [J]. Science 2001, 294:2163～2166.
  • 6Carole A B, Shigeki K, Itaru H. Site-specific discrimination by cyanovirin-N for α-linked trisaccharides comprising the three arms of Man8 and Man9[J]. J Mol Biol, 2002, 322:881～889.
  • 7Tomoya O, Masanao M. Regioselective enhancement of the nucleophilicity of hydroxyl groups through trialkylstannylation: a route to partial alkylation of polyhydroxy compounds [J]. Carbohydr Res. 1978, 62, C1-C4, 1:185～190.
  • 8Laixi W, Yuan C L. The first synthesis of N, N-Diacetyl-Thiochitobiose and related compounds [J]. Carbohydr Lett, 1995,89.
  • 9Alois F, Ingo K. Total synthesis caloporoside [J]. J Org Chem,1998, 63: 3072～3080.
  • 10Alois F, Ingo K. A practical synthesis of β-D-Mannopyranosides [J]. Tetrahedron Lett, 1998, 39:5721～5724.
精细化工中间体
2004年 第3期

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