摘要
目的 研究慢性心力衰竭 (CHF)患者血浆组织型纤溶酶原激活物 (t PA)和纤溶酶原激活物抑制物 1(PAI 1)含量的变化及其临床意义。方法 用酶联免疫吸附法 (ELISA)检测 6 0例CHF患者 (CHF组 )和 2 0例健康体检者 (正常对照组 )血浆t PA及PAI 1抗原含量。结果 CHF组血浆t PA和PAI 1平均含量都明显高于对照组 (P<0 .0 1)。CHF患者血浆PAI 1含量增高随心功能恶化而愈加明显。结论 CHF患者纤溶功能明显下降 ,可用血浆t PA、PAI 1含量作为判断病情的参考指标之一。
Objective To explore the clinical significance and concentration changes of plasma tissue-type plasminogen activator(t-PA) and plasminogen activator inhibitor-1(PAI-1) antigen in patients with chronic heart failure (CHF). Methods Sixty patients with CHF were included in the CHF group, while 20 normal subjects were selected in the normal control (NC) group. The concentrations of plasma t-PA and PAI-1 antigen were simultaneously determined in the CHF group and the NC group by enzyme-linked immunosorbent assay. Results The mean concentrations of plasma t-PA and PAI-1 antigen in the CHF group were significantly higher than those in the NC group(P< 0.01). The more severe the heart failure was, the more marked increases in the concentration of plasma PAI-1 in patients with CHF were. Conclusion The fibrinolytic function in patients with CHF was significantly lower than that in health subjects. Plasma concentration of t-PA or PAI-1 might be an important index for reflecting the endogenous fibrinolytic function during the development of the CHF.
出处
《临床荟萃》
CAS
北大核心
2004年第13期724-726,共3页
Clinical Focus
