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Turner综合征的生长激素治疗 被引量：5

Effects of recombinant buman growth hormone on Turner syndrome
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摘要 Turner 综合征主要表现为矮小和性发育幼稚,使用药物进行早期干预以改善其终身高尤为重要.自20世纪80年代中期基因重组人生长激素(recombinant human growth hormone,rhGH)问世以来,对本病的治疗已成为国内外学者关注的热点.1994~2001年,我院儿科内分泌组应用rhGH治疗Turner综合征20例,观察其用药前后身高增长速率的变化.
作者 江静 傅曼芬 王伟 毛仲英 陈凤生 王德芬
机构地区 上海第二医科大学瑞金医院儿内科
出处 《上海第二医科大学学报》 CSCD 2004年第6期499-500,共2页 Acta Universitatis Medicinalis Secondae Shanghai
关键词 TURNER综合征 生长激素 内分泌 RHGH SHOX基因
分类号 R725.8 [医药卫生—儿科]
  • 相关文献

参考文献10

  • 1[1]Greulich ww, Pyle SI. Radiographic atlas of skeletal development of hand and wrist[M] . 2nd. California: Staford University Press, 1959. 63-183.
  • 2江静,傅曼芬,邱定众,王伟,陈凤生,王德芬.Turner综合征的染色体异常分析[J].上海第二医科大学学报,2003,23(5):413-415. 被引量：7
  • 3陈红珊,杜敏联,苏蕴韵,嵇春旭,沈永年,支涤静,沈水仙,江静,王伟,黄乐,包美珍,张炼,王慕逖,朱逞,谢若翔.253例中国Turner综合征患者的自然生长曲线[J].中华儿科杂志,2001,39(3):141-144. 被引量：24
  • 4[5]Quigley CA, Crown BJ, Anglin DC, et al. Growth hormone and low dose estrogen in Turner syndrome: results of a United States multi center trial to near final height[J]. J Clin Endocrinol Metab, 2002,87(5): 2 033-2 041.
  • 5[6]Barreca A, Larizza D, Damonte G, et al. Insulin like growth factors (IGF I and IGF 2) and IGF binding protein 3 production by fibroblasts of patients with Turner's syndrome in culture[J]. J Clin Endocrinol Metab, 1997, 82(4): 1 041-1 046.
  • 6[7]Kohno H, Honda S. Low urinary growth hormone values in patients with Turner's syndrome[J]. J Clin Endocrinol Metab, 1992, 74(3): 619-622.
  • 7[8]Ross JL, Scott C Jr, Marttila P, et al. Phenotypes associated with SHOX deficiency[J]. J Clin Endocrinol Metab,2001,86(12): 5 674-5 680.
  • 8[9]Gicquel C, Gaston V, Cabrol S, et al. Assessment of Turner's syndrome by molecular analysis of the X chromone in growth retarded girls[J]. J Clin Endocrinal Metab, 1998, 83(5): 1 472-1 476.
  • 9江静,王德芬,陈凤生,孙文鑫,倪继红.重组人生长激素治疗生长激素缺乏症86例疗效分析[J].上海医学,2001,24(11):664-666. 被引量：8
  • 10余慕雪,陈红珊.Turner综合征的治疗进展[J].国外医学（儿科学分册）,2000,27(6):308-310. 被引量：5

二级参考文献14

  • 1Monroy N, Lopez M, Cervantes A, et al. Microsatellite analysis in Turner syndrome:parental origion of X chromosomes and possible mechanism of formation of abnormal chromosomes[ J ]. Am J MealGenet,2002,107(3) : 181 - 189.
  • 2Jalal SM, Dahl R, Erickson L, ct al. Cytogcnctic and clinical characteristics of a case involing complete duplication of X pter→Xq13[ J]. J Med Genet,1996,33(2) :237 -240.
  • 3Boueher CA, Sargent CA, Ogata T, et al. Breakpoint analysis of Turner patients with partial Xp deletions : implieations for the lymphoedema gene location[J]. J Meal Genet,2001,38(9) :591 -598.
  • 4Ogata T, Muroya K, Matsuo N, et al. Turner syndrome and Xp deletions:clinical and molecular studies in 47 patients [ J ] . J Clin Endocrinol Metab ,2001,86( 11 ) :5498 - 5508.
  • 5Ross JL, Scott C Jr, Marttila P, et al. Phenotypes Associated with SHOX Deficiency E J ]. J Clin Endocrinol Metab, 2001,86 ( 12 ) :5674 - 5680.
  • 6Larsen T, Gravholt CH, Yilleheck A, et al. Parental origin of the X chromosome, X chromosome mosaieism and screening for “hidden” Y chromosome in 45, X Turner syndrome ascertained cytogenetieally[J]. Clin Genet,1995,86(1) :6 -11.
  • 7Lespinasse J, Gicquel C, Robert M, et al. Phenotypic and genotypic variability in monozygotlc triplets with Turner syndrome [ J ]. Clin Genet, 1998,54 (1) 56 - 59.
  • 8Ranke MB. Growth disorder in the Ullrich-Turner syndrome [ J ].Baillieres Clin Endocrinol Metab ,1992,6:603-619.
  • 9Quigley CA, Crown B J, Anglin DC, et al. Growth gormone and low dose estrogen in Turner syndrome : results of a United Stat~s multicenter trial to near-final height [ J ]. J Clin Endocrinol Metab,2002,87 ( 5 ) :2033 - 2041.
  • 10Zinn AR, Ross JL. Molecular analysis of genes on Xp controlling Turner syndrome and premature ovarian failure ( POF ) [ J ]. Semin Reprod Meal,2001,19(2) :141 - 146.

共引文献32

同被引文献29

  • 1许薇,孙晓玲,沈楠,张丽.Turner综合征中同种核型不同的临床表现[J].中国优生与遗传杂志,2005,13(3):49-50. 被引量：6
  • 2李欣,潘慧,伍学焱,金自盂,史轶蘩.A case report of Turner syndrome associated with Rathke cleft cyst[J].生殖医学杂志,2005,14(B10):73-74. 被引量：1
  • 3宫剑,熊文栋,杨少燕,陈小芳,曹淑燕.Turner综合征的核型、临床表现与性激素的分析[J].中国优生与遗传杂志,2007,15(3):44-45. 被引量：13
  • 4刘丽,梁雁.卵巢发育异常[M}//颜纯,王慕逖.小儿内分泌学.2版.北京:人民卫生出版社,2006:348.
  • 5Nucarn AL, Melis P, Casini MR, el al. Turner syndrome mosaicism: an unusual case with a de novo large dicentrie marker chromosome: mos 45, X/46, X, ter tea ( X;X ) ( p22. 3:p22. 3 ) [ J ]. J Applied genet, 2008,49 ( 3 ) :301-303.
  • 6Shcheloehkov OA, Cooper ML, Ou Z, et al. Mosaicism for r (X) and der(X)del(X ) (p11.23)dup(X ) (p11.21p11.22) provides insight into the possible mechanism of rearrangement [J].Mol Cytogenet, 2008,1 ( 1 ):16.
  • 7Clement-Jones M, Schiller S, Ran E, et al. The shorl stature homeobox gene SHOX is involved in skeletal abnormalities in Turner syndrome [J]. Human Mol Genet, 2000,9 (5) : 695-702.
  • 8Binder G, Schwarze P, Ranke MB. Identification of short stature caused by SHOX defects and therapeutic effect of recombinant human growlh hormone [ J ]. Clin Endocrinol Metab, 2000,85 ( 1 ) : 245-249.
  • 9Schoemaker M J, Swerdlow AJ, Higgins CD, et al. Cancer incidence in women with Turner syndrome in Great Britain:a national cohort study [ J ]. Lancet Oncol, 2008,9 : 193-195.
  • 10Maggio MC, Liotta A, De-Grazia E, et al. Polycysitic ovary and gonadoblasloma in Turner syndrome [J ]. Minerva Pediatr, 2007, 59 : 397-401.

引证文献5

二级引证文献3

上海第二医科大学学报
2004年 第6期

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