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胸苷磷酸化酶在癌组织中表达的研究 被引量:72

Expression of thymidine phosphorylase in cancer
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摘要 目的 研究胸苷磷酸化酶 (TP)在不同种类癌组织中的表达 ,探讨TP与癌组织血管生成的关系。方法 采用免疫组织化学方法检测 2 5 1例癌组织和相对应的 92例正常组织TP和微血管密度 (MVD)的表达。癌组织包括 :胃癌 4 8例 ,大肠癌 5 3例 ,乳腺癌 4 7例 ,宫颈癌 5 6例 ,肺癌 4 7例 ;正常组织包括 :胃 2 5例 ,大肠 2 5例 ,宫颈 17例 ,肺 2 5例。分析癌组织和正常组织TP表达差异 ,及癌组织TP表达与癌组织MVD的关系。结果 胃癌、大肠癌、乳腺癌、宫颈癌和肺癌的TP表达阳性率分别为6 4 .6 %、6 7.9%、80 .9%、82 .1%和 6 3.8%。癌组织的TP表达阳性率显著高于正常组织 (P =0 .0 0 0 0 )。癌组织TP表达与胃癌、大肠癌、乳腺癌、宫颈癌的MVD值关系密切 (P <0 .0 0 1)。结论 TP在胃癌、大肠癌、乳腺癌、宫颈癌和肺癌组织中过度表达 ,并对胃癌、大肠癌、乳腺癌和宫颈癌的血管生成有明显促进作用。 Objective To study the thymidine phosphorylase (TP) expression in different types of cancer and its correlation with tumor microvessel density (MVD). Methods The expression of TP and MVD was detected by immunohistochemistry method. In a series of 251 cancer patients there were 48 patients with gastric cancer, 53 with colorectal cancer, 47 with breast cancer, 56 with cervical cancer, 47 with lung cancer. Normal gastric (n=25), colorectal (n=25), cervical (n=17) and lung (n=25) tissues around the cancer were also examined. Results The TP expression rate was 64.6% in gastric cancer, 67.9% in colorectal cancer, 80.9% in breast cancer, 82.1% in cervical cancer, and 63.8% in lung cancer, which was significantly higher than that in normal tissues (P=0.0000). TP expression was positively correlated with MVD in gastric, colorectal, breast, and cervical cancers. The correlation was not statistically significant in lung cancer. Conclusion This study indicates that TP overexpression in cancer may be associated with tumor angiogenesis.
出处 《中华肿瘤杂志》 CAS CSCD 北大核心 2004年第5期297-299,共3页 Chinese Journal of Oncology
关键词 胸苷磷酸化酶 TP 癌组织 肿瘤 基因表达 免疫组织 Thymidine phosphorylase Neoplasms Microvessel density
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参考文献2

  • 1李捷,宋三泰,江泽飞,刘晓晴,颜玲娣.血管内皮生长因子及微血管密度在乳腺癌中的表达及意义[J].中华肿瘤杂志,2003,25(2):145-147. 被引量:36
  • 2Hiroyuki Eda,Kaori Fujimoto,Shin-ichi Watanabe,Masako Ura,Ayako Hino,Yutaka Tanaka,Kenji Wada,Hideo Ishitsuka. Cytokines induce thymidine phosphorylase expression in tumor cells and make them more susceptible to 5′-deoxy-5-fluorouridine[J] 1993,Cancer Chemotherapy and Pharmacology(5):333~338

二级参考文献8

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