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米非司酮对小鼠囊胚发育及超微结构的影响 被引量：5

Effects of mifepristone (RU486) on the development and ultrastructure of mouse blastocysts
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摘要 目的:观察米非司酮对小鼠植入前胚胎在体内的生长发育及超微结构的影响。方法:雌性昆明小鼠,随机分为4组,每组15只:对照组(A组),米非司酮剂量1.9 mg/kg组(B组),5.6mg/kg组(C组)和16.8 mg/kg组(D组)。4组动物均按常规超排卵后合笼,在注射hCG后108h～110 h取囊胚观察,并用透射电镜检查4组囊胚超微结构变化。结果:A组和B组囊胚发育率无统计学差异(P>0.05),而C组和D组囊胚发育率显著减少(P<0.05)。随着米非司酮剂量增加,卵裂球表面粗颗粒增多,色泽深暗,卵周隙明显增大。超微结构观察显示,C和D组出现明显的膜、核、细胞器和染色质等超微结构病理改变。结论:米非司酮可损伤小鼠胚胎的超微结构,导致囊胚发育抑制,并呈现明显的剂量效应。
作者 刘新 王自能 朱伟杰
机构地区 暨南大学医学院第一附属医院妇产科教研室 暨南大学生殖免疫研究中心
出处 《生殖与避孕》 CAS CSCD 北大核心 2004年第3期180-182,F003,共4页 Reproduction and Contraception
关键词 米非司酮 囊胚 小鼠 体内 超微结构
分类号 R965 [医药卫生—药理学]
  • 相关文献

参考文献11

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二级参考文献4

共引文献24

同被引文献66

  • 1Catalano RD, Critchley HO, Heikinheimo O, et al. Mifepristone induced reveals novel regulatory Pathways in human endometrium. Mol Hum Reprod, 2007, 13(9): 641-54.
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  • 10Manikkam M, Rajamahendran R. Progesterone-induced atresia of the proestrous dominant follicles in the bovine ovary: changes in diameter, insulin-like growth factor system aromatase activity, steroid hormones and apoptotic index. Biol Reprod, 1997, 57(1):580-7.

引证文献5

二级引证文献12

生殖与避孕
2004年 第3期

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