摘要
目的 研究CD4 4V6在肺癌的表达及其意义。方法 用免疫组化进行CD4 4V6在肺癌组织、癌旁组织及正常肺组织的免疫组化的标记 ,并分析其与肺癌分期、类型及淋巴结转移之间的关系。结果 CD4 4V6在肺癌组织中表达显著高于癌旁组织 ,在非小细胞肺癌中表达显著高于小细胞肺癌 ,与PTNM分期呈显著正相关 ,有淋巴结转移组显著高于无淋巴结转移组。结论 肺癌组织中的CD4 4V6高表达与肺癌的发生发展、淋巴结转移及预后有一定的关系。检测CD4 4V6在肺癌中的表达 。
Objective To study the expression and significance of CD44V6 in lung cancers. Methods The expression of CD44V6 were detected in 60 cases of lung cancer, the same cases of paracancer tissues of lung cancer and 20 cases of normal lung tissues by immunohistochemical method, and its correlations with clinical stages, pathological types, metastatic states of lymph nodes were studied. Results There was high positive expression of CD44V6 in the tissues of NSCLC. The rate of positive expression of CD44V6 had a significant relationship with PTNM and lymph node metastasis in the tissues of NSCLC. Conclusions The high expression of CD44V6 may have a correlation with the development and lymph node metastasis and prognosis of lung cancer. The expression of CD44V6 may be a guideline for predicting the potentiality of lymph node metastasis and prognosis in lung cancer.
出处
《齐齐哈尔医学院学报》
2004年第6期601-603,共3页
Journal of Qiqihar Medical University
