摘要
目的:探讨Wistar大鼠空间参考记忆的年龄及性别差异。方法:Wistar大鼠48只,按年龄和性别分为6组,在Morris水迷宫中比较各组大鼠的空间参考记忆。结果:12月龄大鼠在迷宫中的游泳距离较3月龄组和6月龄组差异有显著性意义。3月龄大鼠性别差异无显著性意义,6月龄雄性大鼠第2天和第3天游泳距离较雌性短,差异有显著性意义(第2天t=3.037,P=0.004;第3天t=1.85,P=0.071),12月龄组雄性大鼠第2天游泳距离较雌性短(t=2.926,P=0.005)。结论:Wistar大鼠空间参考记忆存在年龄、性别差异。
AIM:To investigate the differences between age and sex of spatial reference memory in Wistar rats. METHODS:Forty eight Wistar rats were divided into 6 groups according to sex and age,and Morris water maze was used to test the spatial reference memory. RESULTS:The swimming distance of rats in 12 month old group in the maze was significantly different from that in 3 month group and 6 month group. The rats in 3 month group had no significant differences in sex,but the male rats in 6 month group had shorter swimming distance on the 2nd day and 3rd day than the females with significant differences(2nd day,t=3.037,P=0.004;3rd day t=1.85,P=0.071),and the male rats in 12 month group swimming distance on 2nd day were shorter than females(t=2.926,P=0.005). CONCLUSION:Differences exist in sex and age of spatial reference memory in Wistar rats.
出处
《中国临床康复》
CSCD
2004年第19期3754-3755,共2页
Chinese Journal of Clinical Rehabilitation
