摘要
目的 探讨米非司酮联合氨甲喋呤治疗输卵管异位妊娠的疗效。方法 对早期确诊的102例输卵管异位妊娠患者,口服米非司酮75mg,2次/d,共服3d,另单次肌肉注射氨甲喋呤1mg/kg·b.W.,24h后肌肉注射四氢叶酸钙0.1 mg/kg·b.W.。对照组86例,单次肌肉注射氨甲喋呤1mg/kg·b.w.,24h后肌肉注射四氢叶酸钙0.1 mg/kg·b.w.。结果 94例米非司酮治疗患者治愈率为92.20％。对照组治疗成功70例,治愈率81.4％,两组疗效差异显著(P<0.05)。结论 米非司酮联合氨甲喋呤保守治疗输卵管异位妊娠疗效确切,无明显副作用。
Objective To observe the effects of mifepristone combined with methotrexate for conservative treatment of tubal ectopic pregnancy. Methods A total of 102 cases of tubal ectopic pregnancy diagnosed at early stage were enrolled to receive oral mefepristone at the dose of 75 mg twice daily for 3 d and intramuscular injection with calcium leucovorin at 0.1 mg/kg 24 h after a single dose of methotrexate injection (1 mg/kg· b.w.). In the control group consisting of 86 similar cases, intramuscular injection with calcium leucovorin at 0.1 mg/kg was given 24 h after a single dose of methotrexate (1 mg/kg·b.w.). Results Ninety-four of the 102 cases (92.20%) receiving oral mifepristone combined with calcium leucovorin and methotrexate were cured, a curative rate significantly higher than that in the control group, where 70 cases (81.4%) were cured (P<0.05). Conclusion Mefepristone combined with methotrexate is safe and effective in the treatment of tubal ectopic pregnancy, without obvious side effects.
出处
《第一军医大学学报》
CSCD
北大核心
2004年第7期829-831,共3页
Journal of First Military Medical University
关键词
妊娠
异位/药物疗法
米非司酮
氨甲喋呤
药物疗法
联合
pregnancy, ectopic/drug therapy
mefepristone
methotrexate
drug therapy, combination
