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银杏内酯、刺五加皂甙、人参皂甙对氯化钴诱导化学缺氧的PC12细胞的保护作用 被引量：4

Effect of ginkgolides,Acanthopannx senticosus saponins,ginsenosides on the injury of PC12 cells induced by Cobalt chloride
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摘要 目的 :研究银杏内酯、刺五加皂甙、人参皂甙对氯化钴诱导化学缺氧的 PC12细胞的保护作用。方法 :采用四甲基偶氮唑 (MTT)比色分析法观察银杏内酯 (37.5μg/ m l)、刺五加皂甙 (5 0μg/ ml)、人参皂甙 (6 0μg/ ml)对氯化钴诱导化学缺氧的 PC12细胞活性的影响。结果 :银杏内酯、刺五加皂甙、人参皂甙能显著提高氯化钴诱导缺氧的PC12细胞的活性。结论 :银杏内酯、刺五加皂甙、人参皂甙对氯化钴诱导缺氧损伤的 PC12细胞有明显的保护作用。 Objective:To study the effects of ginkgolides (Gin), Acanthopannx Senticosus Saponins (ASS), ginsenosides (Gs) on the injury of PC12 cells induced by CoCl 2.Methods:The viability of PC12 cells injured by CoCl 2 and pretreated with Gin(37.5μg/ml)、ASS (50μg/ml)、Gs (20μg/ml) was determined by MTT assay.Results:It has been shown that Gin、ASS、Gs enhanced the viability of PC12 cells damaged by CoCl 2.Conclusion:Gin、ASS and Gs have protective effects on chemical hypoxic PC12 cells.
作者 季秋虹 顾建兰 顾永健 朱俐
机构地区 南通医学院航海医学研究所 南通医学院附属医院神经内科
出处 《南通医学院学报》 2004年第3期237-239,共3页 ACTA Academiae Medicinae Nantong
基金 江苏省科技厅基金资助 ( BJ2 0 0 0 0 2 3 ) 交通部重点科技项目 ( 95 -0 4-0 3 -4 1)
关键词 缺氧 PC12细胞 人参皂甙 银杏内酯 刺五加皂甙 氯化钴 Hypoxioi PC12 cell Ginkgolides Acanthopannx Senticosus Saponins Ginsenosides Cobalt chLoride
分类号 R364.4 [医药卫生—病理学]
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  • 1[16]Lando D,Pongratz I,Poellinger L,et al.A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF) 1 alpha and the HIF-like factor [J].J Biol Chem,2000,275 (7):4618-4627.
  • 2[17]Duyndam MC,Hulscher TM,Fontijn D,et al.Induction of vascular endothelial growth factor expression and hypoxia-inducible factor 1 alpha protein by the oxidative stressor arsenite[J].J Biol Chem,2001,276 (51):48066-48076.
  • 3[18]Kimura H,Weisz A,Kurashima Y,et al.Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide:control of hypoxia-inducible factor-1 activity by nitric oxide[J].Blood,2000,95 (1):189-197.
  • 4[19]Semenza GL,Jiang BH,Leung SW,et al.Hypoxia response elements in the aldolase A,enolase 1,and lactate dehydmgenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1 [J].J Biol Chem,1996,271 (51):32529-32537.
  • 5[20]Tanimoto K,Makino Y,Pereira T,et al.Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the yon Hippel-Lindau tumor suppressor protein [J].EMBO J,2000,19 (16):4298-4309.
  • 6[21]Gu J,Milligan J,Huang LE.Molecular mechanism of hypoxia-induclble factor 1alpha-p300 interaction.A leucine-rich interface regulated by a single cysteine[J].J Biol Chem,2001,276 (5):3550-3554.
  • 7[22]Agani FH,Puehowiez M,Chavez JC,et al.Role of nitric oxide in the regulation of HIF-1 alpha expression during hypoxia[J].Am J Physiol Cell Physiol,2002,283 (1):C178-186.
  • 8[1]Wang JY,Shum AY,Wang JY.Hypoxia/reoxygenation induces cell injury via different mechanisms in cultured rat cortical neurons and glial cells[J].Neurosci Lett,2002,322(3):187-191.
  • 9[2]Boseenmeyer C,Chihab R,Muller S,et al.Hypoxia/reoxygenation induces apoptosis through biphasic induction of protein synthesis in cultured rat brain neurons[J].Brain Res,1998,787(1):107-116.
  • 10[3]Wang GL,Semenza GL.Purification and characterization of hypoxia-inducible factor 1 [J].J Biol Chem,1995,270 (3):1230-1237.

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南通医学院学报
2004年 第3期

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