摘要
为评价过氧乙酸消毒剂应用的安全性 ,在实验室对其进行了毒理学试验。结果 ,过氧乙酸消毒剂对小鼠急性经口LD50 为 1882mg/kg ,属低毒级 ;急性吸入毒性LC50 为 2 6g/m3 ,属实际无毒级 ;蓄积毒性K >5 ,为弱蓄积性 ;5g/L过氧乙酸消毒剂对家兔皮肤和眼睛均可引起中等刺激性 ,2g/L过氧乙酸对动物皮肤无刺激 ,对眼睛有轻度刺激 ;3个剂量诱导PCE微核细胞率与阴性对照组比较无显著性差异 (P >0 .0 5 ) ,对小鼠骨髓PCE无诱变作用。
In order to evaluate the safety of use of peracetic acid disinfectant, toxicological test was carried out in laboratory. The results showed that the acute oral LD 50 of the peracetic acid disinfectant for mice was 1882 mg/L, which belongs to low toxicity grade. The acute inhalation toxicity LC 50 was 26 g/m 3 which belongs to actually non-toxic grade. The cumulative toxicity K was >5 which belongs to weak accumulation. 5 g/L peracetic acid disinfectant could cause moderate irritation to rabbit skin and eye and 2 g/L peracetic acid was non-irritative to animal skin and slightly irritative to eye. The rates of PCE micronuclear cells induced by 3 dosages were not different significantly from that of negative control group (P>0.05). No mutagenic effect on mouse bone marrow PCE was observed.
出处
《中国消毒学杂志》
CAS
2004年第3期222-224,共3页
Chinese Journal of Disinfection
关键词
过氧乙酸
刺激性
微核
毒性
peracetic acid
irritation
micronucleus
toxicity
