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凋亡素:一种诱导肿瘤特异性细胞凋亡的病毒蛋白 被引量：7

Apoptin, A Tumor-Specific Viral Death Effector
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摘要 本文对肿瘤特异性细胞凋亡素(apoptin)的研究进展,包括Apoptin的肿瘤特异性细胞凋亡效应和肿瘤治疗应用研究、Apoptin的生物物理和生物化学特性、Apoptin的凋亡功能区域以及细胞核定位对Ap-optin肿瘤特异性凋亡效应的重要性、Apoptin相关蛋白质、肿瘤特异性磷酸激酶对Apoptin的激活作用及正常细胞对Apoptin的中和机制等进行了综述,讨论了Apoptin的激活与肿瘤发生过程的相关性及Apoptin作为一种特异性肿瘤杀手用于肿瘤治疗和作为一种肿瘤特异性感应蛋白用于肿瘤发生研究的前景。 This review will mainly focus on the recent studies on the tumor-specific viral death effector Apoptin, including the tumor-specificity of Apoptin, utility of Apoptin in cancer therapy, biophysical and biochemical properties of Apoptin, death effect domains and importance of nuclear localization for Apoptin-induced apoptosis, Apoptin-associated proteins, activation of Apoptin by its tumor-specific kinase, and the normal-cell neutralization of Apoptin. The relativity of Apoptin activation and tumorigenesis, and the perspectives of Apoptin as a tumor-specific killer for cancer therapy and as a sensor for the basic study of tumorigenesis, will also be discussed.
作者 章应慧 屈伸 Mathieu H.M.Noteborn
机构地区 莱顿大学自然科学院 华中科技大学同济医学院基础医学院生物化学与分子生物学系
出处 《医学分子生物学杂志》 CAS CSCD 2004年第2期63-68,共6页 Journal of Medical Molecular Biology
关键词 凋亡素 细胞凋亡 磷酸激酶 磷酸化 肿瘤发生 Apoptin apoptosis kinase phosphorylation tumorigenesis
分类号 R341 [医药卫生—基础医学]
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参考文献25

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二级参考文献1

共引文献6

同被引文献112

  • 1陈智飞,李一权,胡宁宁,兰添,周晔,李霄,孙丽丽,金宁一.携Apoptin和PEG3启动子双特异性溶瘤腺病毒对结直肠癌的抑制作用[J].中国肿瘤生物治疗杂志,2015,22(1):16-21. 被引量：3
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  • 3闫莹,孙军,毕昊,王小婷,彭冬君,邹珺,王小波,宗义强,屈伸.PTD4-GFP-VP3融合蛋白在人肝癌细胞HepG_2中的定位观察及凋亡诱导效应的实验研究[J].医学分子生物学杂志,2007,4(3):204-208. 被引量：1
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医学分子生物学杂志
2004年 第2期

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